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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sentinel lymph node biopsy after neoadjuvant chemotherapy in inflammatory breast cancer
International Journal of Surgery, Volume 7, No. 3, Year 2009
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Description
Background: Sentinel lymph node biopsy (SLNB) demonstrates promising results as an accurate alternative to axillary lymph node dissection in patients with locally advanced breast cancer after neoadjuvant chemotherapy (NAC). However and in the view of the insufficient data on women with inflammatory breast cancer (IBC), SLNB is not recommended in this situation. The current study assessed identification and false-negative rates of SLNB after NAC for patients with IBC. Methods: Between 2006 and 2009, twenty consecutive patients with clinically negative nodes after NAC for IBC (T4d) and who underwent SLNB and axillary lymph node dissection (levels I and II) by the same operator were assessed. Intraoperative Sentinel lymph node biopsy was performed with patent blue dye injections. Results: The SLN could be identified in 16 of 20 patients (identification rate, 80%), the median of SLN removed per patient was 2 (range 1-3); nine (56%) had positive SLNB, and in 2 of those 9 patients (22%), the SLN was the only positive node with otherwise negative axillary nodes. Two (18%) patients' SLNB were false negative. Conclusions: The SLN identification and false-negative rates after NAC for IBC were unacceptably high and based on the current findings, SLNB without systematic axillary lymph node dissection is unsuitable in this patient population. © 2009 Surgical Associates Ltd.
Authors & Co-Authors
Hidar, Samir
Tunisia, Sousse
Hopital Farhat Hached Sousse
Bibi, Mohammed
Tunisia, Sousse
Hopital Farhat Hached Sousse
Gharbi, Olfa
Tunisia, Sousse
Hopital Farhat Hached Sousse
Tebra, Sameh
Tunisia, Sousse
Hopital Farhat Hached Sousse
Trabelsi, Amel
Tunisia, Sousse
Hopital Farhat Hached Sousse
Korbi, Sadok
Tunisia, Sousse
Hopital Farhat Hached Sousse
Bouaouina, Noureddine
Tunisia, Sousse
Hopital Farhat Hached Sousse
Ben-Ahmed, Slim
Tunisia, Sousse
Hopital Farhat Hached Sousse
Khaïri, Hëdi
Tunisia, Sousse
Hopital Farhat Hached Sousse
Statistics
Citations: 54
Authors: 9
Affiliations: 1
Identifiers
Doi:
10.1016/j.ijsu.2009.04.012
ISSN:
17439191
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Participants Gender
Female