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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Faecal elastase-1 concentration in cystic fibrosis patients with CFTR I1234V mutation
Acta Paediatrica, International Journal of Paediatrics, Volume 95, No. 9, Year 2006
Notification
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Description
Aim: To assess the exocrine pancreatic function among cystic fibrosis patients with cystic fibrosis trans-membrane conductance regulator (CFTR) I1234V mutation. Methods: Cross-sectional study of 40 cystic fibrosis patients with homozygous CFTR I1234V mutation belonging to a large Arab kindred family and 25 healthy subjects as a control group over a period of 12 mo. Assessment of their exocrine pancreatic function was performed by measuring faecal elastase-1 (FE1) concentration with a commercial ELISA kit using polyclonal antibodies (BioServ Diagnostics) in CF patients compared to healthy subjects. The results were compared with those obtained from a second laboratory using another commercial ELISA (ScheBo; Biotech, Germany) that uses two monoclonal antibodies against different specific epitopes of human pancreatic elastase. Results: All CF patients with CFTR I1234V mutation had normal levels of faecal elastase 1. No significant difference was found between the two methods for the CF groups or between the CF patients with and without pancreatic enzyme replacement. Conclusion: Cystic fibrosis with homozygous CFTR I1234V mutation is associated with pancreatic sufficiency. Assessment of exocrine function using polyclonal antibodies does not significantly differ from that using two monoclonal antibodies against different specific epitopes of human pancreatic elastase. © 2006 Taylor & Francis.
Authors & Co-Authors
Abdel Rahman, H.
Qatar, Doha
Hamad Medical Corporation
Abdul Wahab, Atqah
Qatar, Doha
Hamad Medical Corporation
Abdel-Rahman, Mohamed Osman
Qatar, Doha
Hamad Medical Corporation
Mostafa, Ossama Abdel Rahman
Egypt, Beni Suef
Faculty of Medicine
Statistics
Citations: 13
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1080/08035250500538981
ISSN:
08035253
e-ISSN:
16512227
Research Areas
Cancer
Study Design
Randomised Control Trial
Cross Sectional Study
Study Approach
Quantitative