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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A significan sex—but not elective cesarean section—effect on mother-to-child transmission of hepatitis C virus infection
Journal of Infectious Diseases, Volume 61, No. 4, Year 2005
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Description
Background. Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified Methods. We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants. Children with ≥2 positive HCV RNA polymerase chain reaction test results and/or anti-HCV antibodies after 18 months of age were considered to be infected. Results. The overall HCV vertical transmission rate was 6.2% (95% confidenc interval [CI], 5.0%–7.5%; 91/1479). Girls were twice as likely to be infected as boys (adjusted odds ratio [OR], 2.07 [95% CI, 1.23–3.48];). P =.006 There was no protective effect of elective cesarean section (CS) delivery on HCV vertical transmission (adjusted OR, 1.46 [95% CI, 0.86–2.48]; P =.16). HCV/human immunodeficienc virus-coinfected women more frequently transmitted HCV than did women with HCV infection only, although the difference was not statistically significan (adjusted OR, 1.82 [95% CI, 0.94–3.52]; P =.08). Maternal history of injection drug use, prematurity, and breast-feeding were not significantl associated with transmission. Transmission occurred more frequently from viremic women, but it also occurred from a few nonviremic women. Conclusions. Our results strongly suggest that women should neither be offered an elective CS nor be discouraged from breast-feeding on the basis of HCV infection alone. The sex association is an intriguing findin that probably reflect biological differences in susceptibility or response to infection. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Amoroso, Antonio
Italy, Trieste
Università Degli Studi Di Trieste
Asensi-Botet, Francesc
Spain, Valencia
Hospital Universitari I Politècnic la fe
Bona, Gianni C.
Italy, Vercelli
Università Degli Studi Del Piemonte Orientale Amedeo Avogadro
Boucher, Charles A.B.
Netherlands, Utrecht
University Medical Center Utrecht
Butler, Karina M.
Ireland, Dublin
Our Lady's Hospital for Sick Children
Cabero, Luis I.
Spain, Barcelona
Hospital Materno-infantil Vall d' Hebron
Fortuny, Clàudia
Spain, Esplugues de Llobregat
Hospital Sant Joan de Déu Barcelona
Coll, Oriol
Spain, Barcelona
Hospital Clinic Barcelona
de Maria, Andrea F.
Italy, Genoa
Università Degli Studi Di Genova
Cilla, Gustavo
Spain, Donostia-san Sebastian
Osakidetza, Donostia University Hospital
Lanari, Marcello
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Fischler, Björn D.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Bohlin, Ann Britt
Sweden, Stockholm
Karolinska Universitetssjukhuset
Lindgren, Susanne Rosa
Sweden, Stockholm
Karolinska Universitetssjukhuset
Giacomet, Vania
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Mieli- Vergani, Giorgina
United Kingdom, London
King's College Hospital
Hatzakis, Angelos E.
Greece, Athens
National and Kapodistrian University of Athens
Mazza, Antonio
Italy, Trento
Ospedale S. Chiara
Mok, Jacqueline Y.Q.
United Kingdom, Edinburgh
Royal Hospital for Sick Children
Mur-Sierra, Antonío
Spain, Barcelona
Hospital Del Mar
Viñolas, M.
Spain, Barcelona
Hospital Del Mar
Quinti, Isabella
Italy, Rome
Sapienza Università Di Roma
Ferrando, Sara
Italy, Genoa
Università Degli Studi Di Genova
Bassetti, Dante
Italy, Genoa
Università Degli Studi Di Genova
Zuccotti, Gianvincenzo Vincenzo
Italy, Milan
Ospedale San Paolo
Grosch-Wörner, Ilse
Germany, Berlin
Charité – Universitätsmedizin Berlin
Feiterna-Sperling, Cornelia
Germany, Berlin
Charité – Universitätsmedizin Berlin
Piening, Turid
Germany, Berlin
Charité – Universitätsmedizin Berlin
Iorio, R.
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Zanetti, Alessandro Remo
Italy, Milan
Università Degli Studi Di Milano
Tanzi, Elisabetta E.
Italy, Milan
Università Degli Studi Di Milano
Tovo, P.
Italy, Turin
Università Degli Studi Di Torino
Pembrey, Lucy Jane
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Newell, Marie Louise
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Statistics
Citations: 211
Authors: 34
Affiliations: 37
Identifiers
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Case-Control Study
Participants Gender
Male
Female