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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas
Journal of Virology, Volume 84, No. 3, Year 2010
Notification
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Description
Chimpanzees and gorillas are the only nonhuman primates known to harbor viruses closely related to HIV-1. Phylogenetic analyses showed that gorillas acquired the simian immunodeficiency virus SIVgor from chimpanzees, and viruses from the SIVcpz/SIVgor lineage have been transmitted to humans on at least four occasions, leading to HIV-1 groups M, N, O, and P. To determine the geographic distribution, prevalence, and species association of SIVgor, we conducted a comprehensive molecular epidemiological survey of wild gorillas in Central Africa. Gorilla fecal samples were collected in the range of western lowland gorillas (n = 2,367) and eastern Grauer gorillas (n = 183) and tested for SIVgor antibodies and nucleic acids. SIVgor antibody-positive samples were identified at 2 sites in Cameroon, with no evidence of infection at 19 other sites, including 3 in the range of the Eastern gorillas. In Cameroon, based on DNA and microsatellite analyses of a subset of samples, we estimated the prevalence of SIVgor to be 1.6% (range, 0% to 4.6%), which is significantly lower than the prevalence of SIVcpzPtt in chimpanzees (5.9%; range, 0% to 32%). All newly identified SIVgor strains formed a monophyletic lineage within the SIVcpz radiation, closely related to HIV-1 groups O and P, and clustered according to their field site of origin. At one site, there was evidence for intergroup transmission and a high intragroup prevalence. These isolated hot spots of SIVgor-infected gorilla communities could serve as a source for human infection. The overall low prevalence and sporadic distribution of SIVgor could suggest a decline of SIVgor in wild populations, but it cannot be excluded that SIVgor is still more prevalent in other parts of the geographical range of gorillas. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Néel, Cécile
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Etienne, Lucie
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Li, Yingying
United States, Birmingham
The University of Alabama at Birmingham
Takehisa, Jun
United States, Birmingham
The University of Alabama at Birmingham
Rudicell, Rebecca S.
United States, Birmingham
The University of Alabama at Birmingham
Bass, Innocent Ndong
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Moudindo, Joseph
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Mebenga, Aimé
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Esteban, Amandine
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
van Heuverswyn, Fran
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Liégeois, Florian
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Kranzusch, Philip J.
United States, Boston
Harvard Medical School
Walsh, Peter D.
United States, Bethesda
Vaccinape
Sanz, Crickette M.
United States, St. Louis
Washington University in St. Louis
Morgan, David B.
United States, Chicago
Lester E. Fisher Center for the Study and Conservation of Apes
Congo, Brazzaville
Wildlife Conservation Society
Ndjango, Jean Bosco N.
Democratic Republic Congo, Kisangani
Université de Kisangani
Plantier, Jean Christophe
France, Mont-saint-aignan
Université de Rouen Normandie
Locatelli, Sabrina
United States, Albany
State University of new York Albany
Gonder, Mary Katherine
United States, Albany
State University of new York Albany
Leendertz, Fabian Hubertus
Germany, Berlin
Robert Koch Institute
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Boesch, Christophe
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Todd, Angelique F.
Unknown Affiliation
Delaporte, Éric
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Mpoudi-Ngolé, Eitel
Cameroon, Yaounde
Projet Prevention du Sida au Cameroun Presica
Hahn, Beatrice H.
United States, Birmingham
The University of Alabama at Birmingham
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Statistics
Citations: 99
Authors: 26
Affiliations: 13
Identifiers
Doi:
10.1128/JVI.02129-09
ISSN:
0022538X
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon