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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Exposure to Static Magnetic Field of Pregnant Rats Induces Hepatic GSH Elevation But Not Oxidative DNA Damage in Liver and Kidney
Archives of Medical Research, Volume 37, No. 8, Year 2006
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Description
Background: The present investigation was designed to evaluate the effects of subacute exposure to static magnetic field (SMF) on some parameters indicative of oxidative stress and on oxidative DNA damage in pregnant rat. Methods: Females rats (n = 6) were exposed to a SMF (128 mT; 1 h/day) from day 6 to day 19 of pregnancy and were allowed to deliver normally. The control group (n = 6) was not exposed to SMF. Dams were sacrificed 3 days after delivery. The effects of subacute exposure to SMF on oxidative states were assessed on the measurements of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione (GSH) and catalase (CAT). The level of 8-oxo-dG was measured using high-performance liquid chromatography coupled to electrochemical detection. Results: Subacute exposure to SMF failed to alter plasma GPx, MDA, CAT and SOD respectively in liver and kidney. By contrast, SMF increased total GSH (+56%, p <0.05) and reduced GSH (+108%, p <0.05) in liver. Our results showed that the exposure to SMF did not induce oxidative DNA lesions in liver and kidney. Conclusions: The data do not provide evidence that subacute SMF exposure causes DNA damage in liver and kidney in pregnant rats. The present results suggest that hepatic GSH plays an important role in protection against SMF during pregnancy. These changes in antioxidant status (GSH) lead to some adaptive responses due to activation of systems controlling the body oxidative mechanism balance. © 2006 IMSS.
Authors & Co-Authors
Chater, Sihem
Tunisia, Tunis
University of Carthage
France, Grenoble
Cea Grenoble
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Abdelmelek, Hafedh
Tunisia, Tunis
University of Carthage
Douki, Thierry
France, Grenoble
Cea Grenoble
Garrel, Catherine
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Favier, Alain Emile
France, Grenoble
Cea Grenoble
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Sakly, Mohsen
Tunisia, Tunis
University of Carthage
Ben Rhouma, Khémais
Tunisia, Tunis
University of Carthage
Statistics
Citations: 41
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.arcmed.2006.05.010
ISSN:
01884409
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female