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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
In vitro evaluation of the cytotoxicity of different root canal filling materials
Open Dentistry Journal, Volume 5, No. 1, Year 2011
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Description
Objective: Aim of the present study was to evaluate the cytotoxicity of Real Seal 1 compared to other commercially available endodontic filling materials: Real Seal (SybronEndo, Orange, CA, USA) and Thermafil (Tulsa Dental, Tulsa, OK, USA). Material and Methods: Periodontal ligament cells from healthy patients were cultured. The eluate of Real Seal 1TM (RS1), Real Seal (RS) and Thermafil (TF) samples was used for the cells viability tests, both diluted (50%) or undiluted (100%). Incubation of the specimens was performed in culture medium for 24 h, 48 h and 72 h at 37 °C under sterile conditions. The cellular mortality was evaluated by MTT test. Results were statistically analysed and the statistical significance was set at p< 0.05. Results: None of the studied materials showed toxic effects during the period of observation (0 -72 h) when compared to the control group. Only RS induced a very modest increase in cell mortality (about 3% at both concentrations used, during the first 24 hours), when increasing the incubation time, however, only the lower concentration continued to show modest toxicity. Conclusions: Results of the present study showed that all tested materials did not exhibit cytotoxic effects when compared to the control group. © Gambarini et al.
Authors & Co-Authors
Gambarini, Gianluca
Italy, Rome
Sapienza Università Di Roma
Testarelli, Luca
Italy, Rome
Sapienza Università Di Roma
Al-Sudani, Dina
Saudi Arabia, Riyadh
King Saud University
Plotino, Gianluca
Italy, Rome
Sapienza Università Di Roma
Grande, Nicola M.
Italy, Rome
Sapienza Università Di Roma
Lupi, Alessandro
Italy, Rome
Consiglio Nazionale Delle Ricerche
Giardina, Bruno
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Nocca, Giuseppina
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
de Luca, Massimo
Italy, Rome
Sapienza Università Di Roma
Statistics
Citations: 9
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.2174/1874210601105010029
ISSN:
18742106
Research Areas
Environmental
Health System And Policy
Study Design
Randomised Control Trial