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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High level of hepatitis c endemicity in gabon, equatorial africa
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 87, No. 6, Year 1993
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Description
To assess the prevalence of hepatitis C virus (HCV) infection, a community-based study was performed in eastern Gabon on 1172 subjects over 5 years of age. The prevalence of antibodies to HCV (anti-HCV) detected using second-generation enzyme-linked immunosorbent assay (elisa) and confirmed by an immunoblot assay (riba 2), was 6·5%. Anti-HCV prevalence increased with age but was related to neither sex nor ethnic group. Among 30 subjects with positive elisa results, 14 had HCV viraemia as shown by the polymerase chain reaction (11/12 riba positive, 2/15 riba negative, 1/3 riba indeterminate). We conclude that HCV is highly endemic in western equatorial Africa and that a high proportion of the population may be viraemic. © 1993 Oxford University Press.
Authors & Co-Authors
Delaporte, Éric
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Dazza, Marie Christine
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Mlika-Cabanne, Najoua
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Aptel, Isabelle
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Larouzé, Bernard
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Thiers, Valérie
France, Paris
Institut Pasteur, Paris
Bréchot, Christian B.
France, Paris
Institut Pasteur, Paris
Romeo, Raffaella
France, Paris
Hôpital Necker Enfants Malades
Bréchot, Christian
France, Paris
Hôpital Necker Enfants Malades
Schrijvers, Dirk L.A.L.
Gabon, Franceville
Cirm
Statistics
Citations: 54
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/0035-9203(93)90269-V
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Gabon