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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Karyotype analysis in acute nonlymphocytic leukemia (ANLL): Comparison with ethnic group, age, morphology, and survival
Cancer Genetics and Cytogenetics, Volume 6, No. 3, Year 1982
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Description
The karyotype, leukemic cell morphology (FAB classification), ethnic group, age, sex, and survival were compared in 60 patients with acute nonlymphocytic leukemia (ANLL), to determine their diagnostic and prognostic significance. An ethnic age difference was observed; a significantly greater number of black patients were children. The majority of children were males. A higher frequency of chromosome abnormalities was detected in children, yet they survived longer than adults. A specific, significant association between a t(8; 21) karyotype and M2-ANLL was confirmed; four of ten patients with M2-ANLL showed this translocation. The more mature morphology of M2-ANLL was associated with a longer survival irrespective of karyotype, ethnic group, and age. The specificity of t(15; 17) in M3-ANLL and nonrandom monosomy 7 in preleukemic children was confirmed. Patients, particularly adults, with normal karyotypes tended to survive longer than those with abnormal karyotypes. The patient's age and the differentiative capacity of the leukemic cell appear to be as important as the karyotype in determining survival. The nonrandom association of certain chromosome aberrations in ANLL appears to be worldwide. © 1982.
Authors & Co-Authors
Bernstein, Renée
South Africa, Johannesburg
School of Pathology
Pinto, Maximina Rodrigues
South Africa, Johannesburg
School of Pathology
Morcom, G.
South Africa, Johannesburg
School of Pathology
MacDougall, Lorna G.
South Africa, Johannesburg
University of the Witwatersrand
Bezwoda, Werner Robert
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Dukes, Ivan
South Africa, Johannesburg
School of Pathology
Penfold, Grace K.
South Africa, Johannesburg
School of Pathology
Mendelow, Barry Vincent
South Africa, Johannesburg
School of Pathology
Statistics
Citations: 48
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/0165-4608(82)90056-5
ISSN:
01654608
Research Areas
Health System And Policy
Maternal And Child Health