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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Monkey CV1 cell line expressing the sheep-goat SLAM protein: A highly sensitive cell line for the isolation of peste des petits ruminants virus from pathological specimens
Journal of Virological Methods, Volume 173, No. 2, Year 2011
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Description
Peste des petits ruminants (PPR) is an important economically transboundary disease of sheep and goats caused by a virus which belongs to the genus Morbillivirus. This genus, in the family Paramyxoviridae, also includes the measles virus (MV), canine distemper virus (CDV), rinderpest virus (RPV), and marine mammal viruses. One of the main features of these viruses is the severe transient lymphopaenia and immunosuppression they induce in their respective hosts, thereby favouring secondary bacterial and parasitic infections. This lymphopaenia is probably accounted for by the fact that lymphoid cells are the main targets of the morbilliviruses. In early 2000, it was demonstrated that a transmembrane glycoprotein of the immunoglobulin superfamily which is present on the surface of lymphoid cells, the signalling lymphocyte activation molecule (SLAM), is used as cellular receptor by MV, CDV and RPV. Wild-type strains of these viruses can be isolated and propagated efficiently in non-lymphoid cells expressing this protein. The present study has demonstrated that monkey CV1 cells expressing goat SLAM are also highly efficient for isolating PPRV from pathological samples. This finding suggests that SLAM, as is in the case for MV, CDV and RPV, is also a receptor for PPRV. © 2011 Elsevier B.V.
Authors & Co-Authors
Adombi, Caroline M.
Austria, Vienna
International Atomic Energy Agency, Vienna
Lelenta, Mamadou
Austria, Vienna
International Atomic Energy Agency, Vienna
Lamien, Charles Euloge
Austria, Vienna
International Atomic Energy Agency, Vienna
Shamaki, David
Nigeria, Vom
National Veterinary Research Institute, Vom
Koffi, Yao
Cote D'ivoire
Laboratoire Central de Pathologie Animale
Traoré, Abdallah N.
Mali, Bamako
Laboratoire Central Veterinaire Mail
Silber, Roland
Austria, Vienna
Austrian Agency for Health and Food Safety
Couacy-Hymann, Emmanuel
Cote D'ivoire
Laboratoire Central de Pathologie Animale
Bodjo, Sanne Charles
Austria, Vienna
International Atomic Energy Agency, Vienna
Djaman, Joseph Allico
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Luckins, Anthony George
Austria, Vienna
International Atomic Energy Agency, Vienna
Diallo, Adama
Austria, Vienna
International Atomic Energy Agency, Vienna
Statistics
Citations: 105
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1016/j.jviromet.2011.02.024
ISSN:
01660934
Research Areas
Infectious Diseases