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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
In vivo parasitological measures of artemisinin susceptibility
Journal of Infectious Diseases, Volume 201, No. 4, Year 2010
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Description
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites//μL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Stepniewska, K. A.
Unknown Affiliation
Ashley, Elizabeth A.
Unknown Affiliation
Lee, Sue J.
Unknown Affiliation
Anstey, Nicholas M.
Unknown Affiliation
Barnes, Karen Irma
Unknown Affiliation
Binh, Tran Quang
Unknown Affiliation
D'Alessandro, Umberto
Unknown Affiliation
Day, Nichloas P.J.
Unknown Affiliation
de Vries, Peter J.
Unknown Affiliation
Dorsey, Grant M.
Unknown Affiliation
Guthmann, Jean Paul
Unknown Affiliation
Mayxay, Mayfong
Unknown Affiliation
Newton, Paul N.
Unknown Affiliation
Olliaro, Piero L.
Unknown Affiliation
Osorio, Lyda Elena
Unknown Affiliation
Price, Ric N.
Unknown Affiliation
Rowland, Mark W.
Unknown Affiliation
Smithuis, Frank M.
Unknown Affiliation
Taylor, Walter R.J.
Unknown Affiliation
Nosten, François Henry
Unknown Affiliation
White, Nicholas J.
Unknown Affiliation
Statistics
Citations: 166
Authors: 21
Affiliations: 22
Identifiers
Doi:
10.1086/650301
ISSN:
00221899
Research Areas
Infectious Diseases