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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
SNP genotyping identifies new signatures of selection in a deep sample of west African plasmodium falciparum malaria parasites
Molecular Biology and Evolution, Volume 29, No. 11, Year 2012
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Description
We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region. We found little geographic or temporal stratification of the genetic diversity among the sampled parasites. Through application of the iHS and REHH haplotype-based tests for positive selection, we found evidence of recent selective sweeps at a known drug resistance locus, at several known antigenic loci, and at several genomic regions not previously identified as sites of recent selection. We discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors. © 2012 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3472499/bin/supp_29_11_3249__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3472499/bin/supp_mss151_SeneGambia_supp_15May2012.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3472499/bin/supp_mss151_SeneGambia_suppTable1.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3472499/bin/supp_mss151_SeneGambia_suppTable2.xlsx
Authors & Co-Authors
Amambua-Ngwa, Alfred
Unknown Affiliation
Park, Daniel J.
Unknown Affiliation
Volkman, Sarah K.
Unknown Affiliation
Barnes, Kayla G.
Unknown Affiliation
Bei, Amy Kristine
Unknown Affiliation
Lukens, Amanda K.
Unknown Affiliation
Sène, Papa Diogoye
Unknown Affiliation
Van-Tyne, Daria
Unknown Affiliation
Ndiaye, Daouda F.
Unknown Affiliation
Wirth, Dyann F.
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Neafsey, Daniel E.
Unknown Affiliation
Schaffner, Stephen F.
Unknown Affiliation
Statistics
Citations: 37
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1093/molbev/mss151
ISSN:
07374038
e-ISSN:
15371719
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Gambia
Senegal