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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Invasive salmonellosis among children admitted to a Rural Tanzanian Hospital and a comparison with previous studies
PLoS ONE, Volume 5, No. 2, Article e9244, Year 2010
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Description
Background: The importance of invasive salmonellosis in African children is well recognized but there is inadequate information on these infections. We conducted a fever surveillance study in a Tanzanian rural hospital to estimate the case fraction of invasive salmonellosis among pediatric admissions, examine associations with common co-morbidities and describe its clinical features. We compared our main findings with those from previous studies among children in sub-Saharan Africa. Methodology/Principal Findings: From 1 March 2008 to 28 Feb 2009, 1,502 children were enrolled into the study. We collected clinical information and blood for point of care tests, culture, and diagnosis of malaria and HIV. We analyzed the clinical features on admission and outcome by laboratory-confirmed diagnosis. Pathogenic bacteria were isolated from the blood of 156 (10%) children, of which 14 (9%) were S. typhi, 45 (29%) were NTS and 97 (62%) were other pathogenic bacteria. Invasive salmonellosis accounted for 59/156 (38%) bacteremic children. Children with typhoid fever were significantly older and presented with a longer duration of fever. NTS infections were significantly associated with prior antimalarial treatment, malarial complications and with a high risk for death. Conclusions/Significance: Invasive salmonellosis, particularly NTS infection, is an important cause of febrile disease among hospitalized children in our rural Tanzanian setting. Previous studies showed considerable variation in the case fraction of S. typhi and NTS infections. Certain suggestive clinical features (such as older age and long duration of fever for typhoid whereas concomitant malaria, anemia, jaundice and hypoglycemia for NTS infection) may be used to distinguish invasive salmonellosis from other severe febrile illness. © 2010 Mtove et al.
Authors & Co-Authors
Mtove, George A.
Unknown Affiliation
Amos, Ben
Unknown Affiliation
Von-Seidlein, Lorenz
Unknown Affiliation
Hendriksen, Ilse C.E.
Unknown Affiliation
Mwambuli, Abraham
Unknown Affiliation
Kimera, Juma
Unknown Affiliation
Mallahiyo, Rajabu
Unknown Affiliation
Kim, Deokryun
Unknown Affiliation
Ochiai, R. Leon
Unknown Affiliation
Clemens, John David
Unknown Affiliation
Reyburn, Hugh G.
Unknown Affiliation
Magesa, Stephen Masingili
Unknown Affiliation
Deen, Jacqueline L.
Unknown Affiliation
Statistics
Citations: 94
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0009244
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health