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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria
American Journal of Tropical Medicine and Hygiene, Volume 78, No. 2, Year 2008
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Description
Cerebrospinal fluid (CSF) and serum levels of 12 cytokines or chemokines important in central nervous system (CNS) infections were measured in 76 Ugandan children with cerebral malaria (CM) and 8 control children. As compared with control children, children with cerebral malaria had higher cerebrospinal fluid levels of interleukin (IL)-6, CXCL-8/IL-8, granulocyte-colony stimulating factor (G-CSF), tumor necrosis factor-α (TNF-α), and IL-1 receptor antagonist. There was no correlation between cerebrospinal and serum cytokine levels for any cytokine except G-CSF. Elevated cerebrospinal fluid but not serum TNF-α levels on admission were associated with an increased risk of neurologic deficits 3 months later (odds ratio 1.55, 95% CI: 1.10, 2.18, P = 0.01) and correlated negatively with age-adjusted scores for attention (Spearman rho, -0.34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-α production is associated with subsequent neurologic and cognitive morbidity. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
John, Chandy Chiramukhathu
United States, Minneapolis
University of Minnesota Twin Cities
Panoskaltsis-Mortari, Angela
United States, Minneapolis
University of Minnesota Twin Cities
Opoka, Robert Opika
Uganda, Kampala
Makerere University
Park, Gregory S.
United States, Minneapolis
University of Minnesota Twin Cities
Orchard, Paul J.
United States, Minneapolis
University of Minnesota Twin Cities
Jurek, Anne M.
United States, Minneapolis
University of Minnesota Twin Cities
Idro, Richard I.
Uganda, Kampala
Makerere University
Byarugaba, Justus S.
Uganda, Kampala
Makerere University
Boivin, Michael Joseph
United States, East Lansing
Msu College of Osteopathic Medicine
Statistics
Citations: 144
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2008.78.198
ISSN:
00029637
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study