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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Absence of Antibodies to HTLV-III in Health Workers After Hepatitis B Vaccination
JAMA: The Journal of the American Medical Association, Volume 254, No. 8, Year 1985
Notification
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Description
A proportion of the plasma for the triply inactivated, plasma-derived hepatitis B vaccine produced in the United States is obtained from homosexual men. Because homosexual men are a high-risk group for the acquired immunodeficiency syndrome (AIDS), concern has emerged that the vaccine could harbor the AIDS agent. To evaluate this risk, we tested 15-month postvaccination serum samples for antibodies to human T-cell lymphotropic virus type III in 100 health care workers who had received inactivated hepatitis B vaccine lots made from plasma collected between 1977 and 1979 and 100 who had received placebo injections. None of the 200 health workers had serological evidence of human T-cell lymphotropic virus type III infection. These serological findings lend additional support to earlier epidemiologic and immunologic observations suggesting that hepatitis B vaccine does not transmit infection with an AIDS virus. © 1985, American Medical Association. All rights reserved.
Authors & Co-Authors
McLane, Mary Fran
United States, Boston
Harvard T.h. Chan School of Public Health
Snydman, David R.
United States, Boston
Tufts Medical Center
United States, Boston
Tufts University School of Medicine
Polk, B. Frank
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
United States, Baltimore
Johns Hopkins University
Allan, Jonathan S.
United States, Boston
Harvard T.h. Chan School of Public Health
Essex, Max E.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 14
Authors: 5
Affiliations: 10
Identifiers
Doi:
10.1001/jama.1985.03360080076033
ISSN:
00987484
Research Areas
Infectious Diseases
Participants Gender
Male