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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Is
18
F-fluorodeoxyglucose positron emission tomography meaningful for estimating the efficacy of corticosteroid therapy in patients with autoimmune pancreatitis?
Journal of Hepato-Biliary-Pancreatic Sciences, Volume 17, No. 3, Year 2010
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Description
Background: Autoimmune pancreatitis (AIP) is often misdiagnosed as pancreatic cancer (PC). Both conditions accumulate 18F- fluorodeoxyglucose (FDG), so FDG positron emission tomography (FDG-PET) is not discriminatory. This study aimed to evaluate the pattern of FDG accumulation, and the change in FDG uptake after steroid treatment in AIP and PC. Methods: We compared FDG-PET patterns between 18 patients with AIP and 20 patients with PC, and also evaluated the short-term changes in FDG uptake after steroid therapy. Results: FDG uptake was observed in 88.9% in AIP and 90.0% in PC. FDG uptake in extra-abdominal lymph nodes was seen more frequently in AIP, and uptake in salivary glands, eyes and biliary ducts was seen only in AIP. Follow-up PET was performed in 6 AIP patients and in 3 PC patients. Changes in SUVmax after steroid therapy were estimated within 1 week in 5 AIP patients and in all 3 PC patients, retrospectively. In 4 AIP patients, the change in SUV max was more than 10%. On the other hand, in PC, SUVmax increased or remained almost unchanged (within 10%). Conclusions: FDG-PET pattern at baseline, and a decrease in FDG uptake after a short steroid trial can be useful for discriminating AIP from PC. © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2009.
Authors & Co-Authors
Shigekawa, Minoru
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Japan, Suita
Graduate School of Medicine
Yamao, Kenji
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Sawaki, Akira
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Hara, Kazuo
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Takagi, Tadayuki
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Bhatia, Vikram K.
India, New Delhi
Institute of Liver and Biliary Sciences
Nishio, Masami
Japan, Nagoya
Nagoya Pet Imaging Center
Tamaki, Tsuneo
Japan, Nagoya
East Nagoya Imaging Diagnosis Center
El-Amin, Hussein Ahmed
Egypt, Asyut
Assiut University
El-Abdeen, Zain
Egypt, Asyut
Assiut University
Sayed, Ahmed
Egypt, Asyut
Assiut University
Mizuno, Nobumasa
Japan, Nagoya
Aichi Cancer Center Hospital and Research Institute
Statistics
Citations: 12
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1007/s00534-009-0172-9
ISSN:
18686974
e-ISSN:
18686982
Research Areas
Cancer
Environmental
Health System And Policy
Study Design
Cohort Study