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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: Systematic review and meta-analysis
Clinical Pharmacology and Therapeutics, Volume 92, No. 6, Year 2012
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Description
A systematic review and a meta-analysis were performed to quantify the accumulated information from genetic association studies investigating the impact of the CYP4F2 rs2108622 (p.V433M) polymorphism on coumarin dose requirement. An additional aim was to explore the contribution of the CYP4F2 variant in comparison with, as well as after stratification for, the VKORC1 and CYP2C9 variants. Thirty studies involving 9,470 participants met prespecified inclusion criteria. As compared with CC-homozygotes, T-allele carriers required an 8.3% (95% confidence interval (CI): 5.6-11.1%; P0.0001) higher mean daily coumarin dose than CC homozygotes to reach a stable international normalized ratio (INR). There was no evidence of publication bias. Heterogeneity among studies was present (I 2 = 43%). Our results show that the CYP4F2 p.V433M polymorphism is associated with interindividual variability in response to coumarin drugs, but with a low effect size that is confirmed to be lower than those contributed by VKORC1 and CYP2C9 polymorphisms. © 2012 American Society for Clinical Pharmacology and Therapeutics.
Authors & Co-Authors
Danese, Elisa
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Montagnana, Martina
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Johnson, Julie A.
United States, Gainesville
University of Florida
Zambon, Carlo Federico
Italy, Padua
Università Degli Studi Di Padova
Lubitz, Steven A.
United States, Boston
Massachusetts General Hospital
Suarez-Kurtz, Guilherme
Brazil, Rio de Janeiro
Instituto Nacional de Cancer
Cavallari, Larisa H.
United States, Chicago
University of Illinois at Chicago
Zhao, Lizi
China, Guangzhou
Sun Yat-sen University
Huang, Ming
China, Guangzhou
Sun Yat-sen University
Nakamura, Yusuke
Japan, Tokyo
The University of Tokyo
Mushiroda, Taisei
Japan, Wako
Riken
Kringen, Marianne Kristiansen
Norway, Oslo
Oslo Universitetssykehus
Borgiani, Paola
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Ciccacci, Cinzia
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Langaee, Taimour Yousef
United States, Gainesville
University of Florida
Siguret, Virginie
France, Paris
Université Paris Cité
Loriot, Marie Anne
France, Paris
Université Paris Cité
Sagreiya, Hersh
United States, Palo Alto
Stanford University
Altman, Russ B.
United States, Palo Alto
Stanford University
Shahin, Mohamed Hossam A.
United States, Gainesville
University of Florida
Scott, Stuart A.
United States, New York
Icahn School of Medicine at Mount Sinai
Khalifa, Sherief Ibrahim
Qatar, Doha
Qatar University
Chowbay, Balram
Singapore, Singapore City
National Cancer Centre, Singapore
Suriapranata, Ivet Marita
Indonesia, Tangerang
Universitas Pelita Harapan
Stricker, Bruno H.Ch
Netherlands, Rotterdam
Erasmus Mc
Taljaard, Monica K.
Canada, Ottawa
University of Ottawa
Zhang, Jieying Eunice
United States, Albany
New York State Department of Health
Pirmohamed, Munir
United Kingdom, Liverpool
University of Liverpool
Carlquist, John F.
United States, Murray
Intermountain Medical Center
Horne, Benjamin D.
United States, Murray
Intermountain Medical Center
Lee, Ming Ta Michael
Taiwan, Nankang
Academia Sinica Taiwan
Minuz, Pietro
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Fava, Cristiano
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Sweden, Lund
Skånes Universitetssjukhus
Statistics
Citations: 62
Authors: 33
Affiliations: 26
Identifiers
Doi:
10.1038/clpt.2012.184
ISSN:
15326535
Research Areas
Genetics And Genomics
Study Approach
Systematic review