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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association between lymphocyte and monocyte subsets and cognition in children with HIV
AIDS Research and Therapy, Volume 11, No. 1, Article 7, Year 2014
Notification
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Description
Background: This study assesses the relationships between lymphocyte and monocyte subsets and intelligence quotient (IQ) scores in antiretroviral therapy (ART)-naive, HIV-infected Thai children without advanced HIV disease.Findings: Sixty-seven ART-naive Thai children with CD4 between 15-24% underwent cognitive testing by Weschler intelligence scale and had 13 cell subsets performed by flow cytometry including naive, memory and activated subsets of CD4+ and CD8+ T cells, activated and perivascular monocytes and B cells. Regression modelling with log10 cell count and cell percentage transformation was performed.Median age (IQR) was 9 (7-10) years, 33% were male, CDC stages N:A:B were 1:67:31%, median CD4% and count (IQR) were 21 (18-24)%, 597 (424-801) cells/mm3 and HIV RNA (IQR) was 4.6 (4.1-4.9) log10 copies/ml. Most (82%) lived at home, 45% had a biological parent as their primary caregiver, and 26 (49%) had low family income. The mean (SD) scores were 75 (13) for full scale IQ (FIQ), 73 (12) for verbal IQ (VIQ) and 80 (14) for performance IQ (PIQ). Adjusted multivariate regression analysis showed significant negative associations between B cell counts and FIQ, VIQ and PIQ (p < 0.01 for all); similar associations were found for B cell percentages (p < 0.05 for all).Conclusions: High B cell counts and percentages were strongly associated with poorer FIQ, VIQ and PIQ scores. Prospective, long-term assessment of cell subsets and determination of relevant B cell subpopulations could help further elucidate associations between lymphocyte subsets and neurocognitive development. © 2014 Ananworanich et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Ananworanich, Jintanat
Thailand, Bangkok
Thai Red Cross Agency
Thailand, Bangkok
Chulalongkorn University
Australia, Sydney
Unsw Sydney
Bunupuradah, Torsak
Thailand, Bangkok
Thai Red Cross Agency
Apornpong, Tanakorn
Thailand, Bangkok
Thai Red Cross Agency
Kosalaraksa, Pope
Unknown Affiliation
Hansudewechakul, Rawiwan
Thailand, Chiang Rai
Chiangrai Prachanukroh Hospital
Kanjanavanit, Suparat
Thailand, Chaing Mai
Nakornping Hospital
Ngampiyaskul, Chaiwat
Unknown Affiliation
Luesomboon, Wicharn
Unknown Affiliation
Ngo-Giang-Huong, Nicole
Unknown Affiliation
Jaimulwong, Tanyathip
Thailand, Bangkok
Thai Red Cross Agency
Kerr, Stephen J.
Thailand, Bangkok
Thai Red Cross Agency
Australia, Sydney
Unsw Sydney
Brouwers, Pim Y.
United States, Bethesda
Instituto Nacional de la Salud Mental
Shearer, William Thomas
United States, Houston
Baylor College of Medicine
Puthanakit, Thanyawee
Thailand, Bangkok
Thai Red Cross Agency
Thailand, Bangkok
Chulalongkorn University
Phanuphak, Praphan
Unknown Affiliation
Ruxrungtham, Kiat
Thailand, Bangkok
Chulalongkorn University
Saphonn, Vonthanak
Unknown Affiliation
Kaldor, John M.
Unknown Affiliation
Cooper, David A.
Unknown Affiliation
Chokephaibulkit, Kulkanya
Unknown Affiliation
Sirisanthana, Virat
Unknown Affiliation
Suntarattiwong, Piyarat
Unknown Affiliation
Cotton, Mark Fredric
Unknown Affiliation
Giaquinto, Carlo
Unknown Affiliation
Lolekha, Rangsima
Unknown Affiliation
Fox, Lawrence M.
United States, Bethesda
National Institutes of Health Nih
Ussery, Michael A.
United States, Bethesda
National Institutes of Health Nih
Mofenson, Lynne M.
United States, Bethesda
National Institutes of Health Nih
Valcour, Victor G.
Unknown Affiliation
Paul, Robert H.
Unknown Affiliation
Pattanapanyasat, Kovit
Unknown Affiliation
McNicholl, Janet M.
Unknown Affiliation
Gelman, Rebecca Sue
Unknown Affiliation
Pancharoen, Chitsanu
Thailand, Bangkok
Chulalongkorn University
Mahanontharit, Apicha
Thailand, Bangkok
Chulalongkorn University
Suwanlerk, Tulathip
Thailand, Bangkok
Chulalongkorn University
Intasan, Jintana
Thailand, Bangkok
Chulalongkorn University
Phadungphon, Chowalit
Thailand, Bangkok
Chulalongkorn University
Eampokalap, Boonchuay
Unknown Affiliation
Lumbiganon, Pagakrong
Unknown Affiliation
Tharnprisan, Piangjit
Unknown Affiliation
Lulitanond, Viraphong
Unknown Affiliation
Chutima, Duangrat
Thailand, Chaing Mai
Nakornping Hospital
Thaweesombat, Yupawan
Thailand, Chiang Rai
Chiangrai Prachanukroh Hospital
Srisawat, Nattachai
Unknown Affiliation
Chamjamrat, Wanna
Unknown Affiliation
Statistics
Citations: 2
Authors: 46
Affiliations: 8
Identifiers
Doi:
10.1186/1742-6405-11-7
ISSN:
17426405
Research Areas
Infectious Diseases
Maternal And Child Health
Mental Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male