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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A new deep branch of eurasian mtDNA macrohaplogroup M reveals additional complexity regarding the settlement of Madagascar
BMC Genomics, Volume 10, Article 605, Year 2009
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Description
Background: Current models propose that mitochondrial DNA macrohaplogroups M and N evolved from haplogroup L3 soon after modern humans left Africa. Increasingly, however, analysis of isolated populations is filling in the details of, and in some cases challenging, aspects of this general model.Results: Here, we present the first comprehensive study of three such isolated populations from Madagascar: the Mikea hunter-gatherers, the neighbouring Vezo fishermen, and the Merina central highlanders (n = 266). Complete mitochondrial DNA genome sequences reveal several unresolved lineages, and a new, deep branch of the out-of-Africa founder clade M has been identified. This new haplogroup, M23, has a limited global distribution, and is restricted to Madagascar and a limited range of African and Southwest Asian groups.Conclusions: The geographic distribution, phylogenetic placement and molecular age of M23 suggest that the colonization of Madagascar was more complex than previously thought. © 2009 Ricaut et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2808327/bin/1471-2164-10-605-S1.XLS
https://efashare.b-cdn.net/share/pmc/articles/PMC2808327/bin/1471-2164-10-605-S2.XLS
https://efashare.b-cdn.net/share/pmc/articles/PMC2808327/bin/1471-2164-10-605-S3.DOC
Authors & Co-Authors
Ricaut, François Xavier
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Belgium, Leuven
Ku Leuven
Razafindrazaka, Harilanto
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Cox, Murray P.
New Zealand, Palmerston North
Massey University
Dugoujon, Jean Michel H.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Guitard, Evelyne
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Sambo, Clement
Madagascar, Tulear
Université de Toliara
Mormina, Maru
United Kingdom, Cambridge
University of Cambridge
Mirazón Lahr, Marta
United Kingdom, Cambridge
University of Cambridge
Ludes, Bertrand P.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
France, Strasbourg
Institut de Médecine Légale de Strasbourg
Crubézy, Éric
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Statistics
Citations: 54
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2164-10-605
e-ISSN:
14712164
Research Areas
Genetics And Genomics
Study Locations
Madagascar