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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antibody responses to several malaria pre-erythrocytic antigens as a marker of malaria exposure among travelers
American Journal of Tropical Medicine and Hygiene, Volume 74, No. 6, Year 2006
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Description
Protective devices against vectors are used by travelers in malaria-endemic areas but their efficacy for protection against mosquitoes has rarely been evaluated. The level of exposure to malaria transmission of 205 soldiers deployed in Africa and the efficacy of their anti-vector prophylaxis was evaluated by comparison of their IgM and IgG responses against five pre-erythrocytic Plasmodium falciparum antigens (circumsporozoite protein, sporozoite threonine-and asparagine-rich protein, sporozoite- and liver-stage antigen, liver stage antigen 1, and SR11.1) before and at the end of their deployment, and three months after returning to France for 106 of these soldiers. The immune responses increased significantly during the mission in 35% (95% confidence interval = 28-42%) of the individuals. The permanent use of insecticide-treated bed nets and long-sleeve battle dress at night were associated with protective efficacy. The analysis of these antibody responses was sensitive enough to evaluate exposure to malaria transmission and the efficacy of anti-vector devices in travelers using antimalarial chemoprophylaxis. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Orlandi-Pradines, Ève
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Penhoat, Kristell
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Pons, Christophe
Unknown Affiliation
Pradines, Bruno
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Fusaï, Thierry
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Josse, Richard L.
France, Villenave-d'ornon
Hôpital D'instruction Des Armées Robert Picqué
Meynard, Jean Baptiste
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Durand, Jean Paul A.
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Migliani, René
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Boutin, Jean Paul
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Druilhe, Pierre L.
France, Paris
Institut Pasteur, Paris
Rogier, Christophe
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Statistics
Citations: 32
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2006.74.979
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases