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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study
Gynecological Endocrinology, Volume 27, No. 10, Year 2011
Notification
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Description
Background.Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women. Patient and method.We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy. Three-hundred and sixty non-diabetic PCOS patients were included who were conceived on metformin by different treatment modalities. Two-hundred pregnant women continued on metformin at a dose of 10002000mg daily throughout pregnancy (study group) and 160 women discontinued metformin use at the time of conception (control group). Results.There is a statistically significant reduction in the incidence of GDM in favor of metformin group (OR: 0.17, 95% CI: 0.070.37). There is a statistically significant reduction in the incidence of pre-eclampsia in favor of metformin group (OR: 0.35, 95% CI: 0.130.94). Conclusion.Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women. © 2011 Informa UK, Ltd.
Authors & Co-Authors
Khattab, Sherif M.
Egypt
Miser International Hospital
Egypt, Cairo
Faculty of Medicine
Mohsen, Iman Abdel
Egypt
Miser International Hospital
Egypt, Cairo
Faculty of Medicine
Aboul Foutouh, I.
Egypt
Miser International Hospital
Egypt, Cairo
Faculty of Medicine
Ashmawi, H. Salah El Din
Egypt
Miser International Hospital
Egypt, Cairo
Faculty of Medicine
Mohsen, M. N.
Egypt
Miser International Hospital
Egypt, Beni Suef
Beni-suef University
Van Wely, Madelon
Netherlands, Amsterdam
Universiteit Van Amsterdam
van der Veen, Fulco V.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Youssef, M. A.F.M.
Egypt
Miser International Hospital
Egypt, Cairo
Faculty of Medicine
Netherlands, Amsterdam
Universiteit Van Amsterdam
Statistics
Citations: 70
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.3109/09513590.2010.540600
e-ISSN:
14730766
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Female