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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Longitudinal analysis of CD8 T-cell responses to HIV and hepatitis C virus in a cohort of co-infected haemophiliacs
AIDS, Volume 19, No. 11, Year 2005
Notification
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Description
Objective: To investigate CD8 T-cell responses to HIV and hepatitis C virus (HCV) over time in a group of co-infected children with haemophilia to assess the influence of the virus infections on each other and on clinical outcome. Design: The HIV and HCV CD8 T-cell response of HLA-A2 co-infected individuals in the cohort were analysed at two time points, looking at the frequency and phenotype of HIV-specific T cells and assessing overall responses to the two viruses. Methods: Peripheral blood mononuclear cells (PBMC) from 72 HLA-A2 co-infected individuals were analysed using an HIV HLA-A2 tetramer and by IFN-γ ELISpot using a panel of HIV and HCV antigens. PBMC from a group of 26 HLA-A2 HIV mono-infected adults were also analysed as a comparison. Results: We identified two distinct patterns of response: some patients had a limited response to either virus whilst others made responses to a range of HIV epitopes. HCV responses were detected only in those who made multiple responses to HIV epitopes (P<0.0001). HCV infection had an influence on the phenotype of HIV-specific CD8 T cells, with a reduction in relative perforin and CD57 expression. Lack of functional or tetramer-positive HIV-specific T cells was associated with a decline in absolute CD4 T-cell counts between the time points (up to 7 years; P = 0.005). Conclusion: HCV infection has an impact on the phenotype of HIV-specific CD8 T cells. In this well-defined cohort, failure to maintain effective CD8 T-cell responses against HIV may contribute to disease progression. © 2005 Lippincott Williams & Wilkins.
Authors & Co-Authors
Donfield, Sharyne M.
United States, Chapel Hill
Rho
Gomperts, Edward D.
United States, Los Angeles
Children's Hospital Los Angeles
Daar, Eric S.
United States, Los Angeles
University of California, Los Angeles
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
University of Oxford
Phillips, Rodney E.
United Kingdom, Oxford
University of Oxford
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 10
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1097/01.aids.0000176213.10367.05
ISSN:
02699370
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study