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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients
Diabetes Research and Clinical Practice, Volume 103, No. 1, Year 2014
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Description
Aims: We investigated the prevalence of diabetes autoantibodies (Abs) in Cameroonian patients and controls, assessed their contribution in disease classification and compared results with data from Belgium. Methods: Abs against GAD (GADA), IA-2 (IA-2A) and zinc transporter 8 (ZnT8A) were assessed in 302 recently diagnosed Cameroonian patients with diabetes and 184 control subjects without diabetes aged below 40 years. Results: Only 27 (9%) Cameroonian patients were younger than 15 years. Overall, 29% of patients presented at least one diabetes-associated antibody vs 9% in healthy controls (24% vs 7% for GADA (p<0.001), 10% vs 3% for IA-2A (p<0.006), 4% vs 2% for ZnT8A). Ab+ patients had lower C-peptide levels (p<0.001), were more often insulin-treated (p<0.002) and were as frequently diagnosed with type 1 diabetes as Ab- patients. Only 43% of Ab+ patients aged 15-39 years were clinically classified as having type 1 diabetes in Cameroon vs 96% in Belgium (p<0.001). Not one Ab+ Cameroonian patient carried HLA-DQ2/DQ8 genotype vs 23% of Belgian Ab+ patients (p<0.001). Younger age at diagnosis and antibody positivity were independent predictors of insulin therapy. Ab+ Cameroonian patients were older (p<0.001), had higher BMI (p<0.001) and lower Ab titers than Belgian Ab+ patients. In ketonuric patients, prevalence of autoantibodies was similar as in non-ketonuric patients. Conclusions: In Cameroonian patients with diabetes aged under 40 years, antibody-positivity is not clearly related to disease phenotype, but may help predict the need for insulin treatment. © 2013 Elsevier Ireland Ltd.
Authors & Co-Authors
Asanghanwa, M.
Belgium, Brussels
Free Universities of Brussels
Gorus, Frans K.
Belgium, Brussels
Free Universities of Brussels
Belgium, Jette
Universitair Ziekenhuis Brussel
Weets, Ilse
Belgium, Brussels
Free Universities of Brussels
Belgium, Jette
Universitair Ziekenhuis Brussel
der Auwera, Bart Van
Belgium, Brussels
Free Universities of Brussels
Aminkeng, Folefac
Canada, Vancouver
The University of British Columbia
Mbunwe, Eric
Belgium, Brussels
Free Universities of Brussels
Goubert, Patrick
Belgium, Jette
Universitair Ziekenhuis Brussel
Verhaeghen, Katrijn
Belgium, Jette
Universitair Ziekenhuis Brussel
Sobngwi, Eugène
Cameroon, Yaounde
Université de Yaoundé I
Wenzlau, Janet M.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Hutton, John C.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Pipeleers, Daniël G.
Belgium, Brussels
Free Universities of Brussels
Keymeulen, Bart
Belgium, Brussels
Free Universities of Brussels
Belgium, Jette
Universitair Ziekenhuis Brussel
Mbanya, J. C.
Cameroon, Yaounde
Université de Yaoundé I
van Schravendijk, Christiaan F.H.
Belgium, Brussels
Free Universities of Brussels
Statistics
Citations: 16
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1016/j.diabres.2013.11.013
ISSN:
01688227
e-ISSN:
18728227
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Cameroon