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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Effect of Intraportal Prostaglandin E1 on Adhesion Molecule Expression, Inflammatory Modulator Function, and Histology in Canine Hepatic Ischemia/Reperfusion Injury
Journal of Surgical Research, Volume 138, No. 1, Year 2007
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Description
Background: Prostaglandin E1 (PGE1) is known to protect the liver from I/R, however, the mechanism of cytoprotection is not well understood. This study investigates the effect of intraportal infusion of PGE1 in a warm liver ischemia/reperfusion (I/R) model on cytokines, adhesion molecules and liver structure. Materials and methods: Twenty dogs underwent laparotomy under general anesthesia. PGE1 (0.02 μg\kg\min) was perfused through the portal vein in the PGE1 group (n = 10), or a similar volume of Ringer's solution in the control group (n = 10) for 15 min. Liver ischemia was induced by hepatic artery and portal vein occlusion and PGE1 was infused via the portal vein for 60 min. The occlusion was released and PGE1 infusion recommenced for 30 min. Blood and liver biopsies were sampled at baseline, 60 min ischemia, and 30 min reperfusion and assessed for transaminases, cytokines, adhesion molecules, and electron microscopy. Results: PGE1 infusion significantly reduced transaminases TNF-α, sICAM-1, sP-selectin, and sE-selectin on ischemia and reperfusion. PGE1 reduced hepatocytic degeneration, portal and central ICAM-1 expression, central and sinusoidal VCAM-1 expression, portal and central P-selectin expression, and portal and sinusoidal E-selectin expression on reperfusion. Conclusion: Intraportal PGE1 infusion reduced I/R injury and was associated with down-regulation of ICAM-1, VCAM-1, P-selectin, and E-selectin on reperfusion. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hafez, Tariq
United Kingdom, London
Ucl Medical School
Moussa, Mona Mohammed
Egypt, Giza
Clinical Lab Research Division
Nesim, Iris
Egypt, Giza
Clinical Lab Research Division
Baligh, Nadia
Egypt, Giza
Clinical Lab Research Division
Davidson, Brian Ritchie
United Kingdom, London
Ucl Medical School
Abdul-Hadi, Ahmed
Egypt, Giza
Clinical Lab Research Division
Statistics
Citations: 47
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.jss.2006.05.009
ISSN:
00224804
e-ISSN:
10958673
Research Areas
Violence And Injury
Study Design
Randomised Control Trial