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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adherence and acceptability in MTN 001: A randomized cross-over trial of daily oral and topical tenofovir for HIV prevention in women
AIDS and Behavior, Volume 17, No. 2, Year 2013
Notification
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Description
We compared adherence to and acceptability of daily topical and oral formulations of tenofovir (TFV) used as pre-exposure prophylaxis (PrEP) for HIV prevention among women in South Africa, Uganda and the United States. 144 sexually active, HIV-uninfected women participated in a cross-over study of three regimens: oral tablet, vaginal gel, or both. We tested for differences in adherence and evaluated product acceptability. Self-reported adherence for all regimens was high (94 %), but serum TFV concentrations indicated only 64 % of participants used tablets consistently. Most women in the U.S. (72 %) favored tablets over gel; while preferences varied at the African sites (42 % preferred gel and 40 % tablets). Findings indicate a role for oral and vaginal PrEP formulations and highlight the importance of integrating pharmacokinetics-based adherence assessment in future trials. Biomedical HIV prevention interventions should consider geographic and cultural experience with product formulations, partner involvement, and sexual health benefits that ultimately influence use. © 2012 Springer Science+Business Media New York.
Authors & Co-Authors
Minnis, Alexandra M.
United States, Research Triangle Park
Rti International
United States, Berkeley
University of California, Berkeley
Gandham, Sharavi
United States, Seattle
Scharp
Richardson, Barbra Ann
United States, Seattle
University of Washington
Guddera, Vijay
South Africa, Tygerberg
South African Medical Research Council
Chen, Beatrice A.
United States, Pittsburgh
University of Pittsburgh
Salata, Robert A.
United States, Cleveland
Case Western Reserve University
Nakabiito, Clemensia
Uganda, Kampala
Mujhu Research Collaboration
Hoesley, Craig J.
United States, Birmingham
The University of Alabama at Birmingham
Justman, Jessica E.
United States, New York
Mailman School of Public Health
Soto-Torres, Lydia E.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Patterson, Karen B.
United States, Seattle
University of Washington
Gomez, Kailazarid
United States, Durham
Fhi360
Hendrix, Craig W.
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 79
Authors: 13
Affiliations: 13
Identifiers
Doi:
10.1007/s10461-012-0333-8
ISSN:
10907165
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Locations
South Africa
Uganda
Participants Gender
Female