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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictors of rapid HIV testing acceptance and successful nevirapine administration in zambian labor wards
Journal of Acquired Immune Deficiency Syndromes, Volume 52, No. 2, Year 2009
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Description
BACKGROUND: Provision of HIV testing in labor provides an opportunity to reach susceptible women and infants. METHODS: As part of a cluster randomized trial of labor ward-based prevention of mother-to-child transmission services in Lusaka, Zambia, we determined predictors of testing acceptance and nevirapine (NVP) administration in labor. HIV counseling and testing were offered to women unaware of their HIV status. NVP was administered to women who tested positive, and an inert (calcium) tablet was provided to women who tested negative, to avoid stigmatization. RESULTS: Among the 2435 women who presented in labor, 393 (16%) were unaware of their HIV status, of whom 278 (71%) met eligibility criteria. We offered counseling to 217 (78%) of eligible women: 146 (67%) agreed, 82 (56%) of those counseled were tested for HIV, and 23 (28%) were seropositive. Testing rates were higher among primigravida women [adjusted odds ratio (AOR) 1.5; 95% confidence interval (CI): 1.1 to 2.1] and among those not offered HIV testing during their pregnancy (AOR 3.7; 95% CI: 2.8 to 5.1). Cervical dilation ≤3 cm at the time of admission was associated strongly with NVP ingestion >1 hour (AOR 11.5; 95% CI: 4.5 to 29.2) and >2 hours (AOR 11.4; 95% CI: 4.7 to 27.5) before delivery. CONCLUSION: Labor ward HIV testing is feasible in this resource-limited setting. Copyright © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Megazzini, Karen M.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
United States, Rockville
Westat, Inc.
Chintu, Namwinga T.
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Vermund, Sten Havlor
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
United States, San Francisco
Institute for Global Health
United States, Nashville
Vanderbilt University School of Medicine
Redden, David T.
United States, Birmingham
The University of Alabama at Birmingham
Krebs, Daniel W.
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Simwenda, Maureen
Zambia, Lusaka
University of Zambia School of Medicine
Tambatamba, Bushimbwa
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Sinkala, Moses M.
Zambia, Lusaka
Catholic Medical Mission Board
Stringer, Jeffrey S.A.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Zambia, Lusaka
University of Zambia School of Medicine
Statistics
Citations: 9
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1097/QAI.0b013e3181ab6e7c
ISSN:
15254135
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Case-Control Study
Study Locations
Zambia
Participants Gender
Female