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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: A prospective cohort study from ADVANCE
European Journal of Preventive Cardiology, Volume 18, No. 2, Year 2011
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Description
Aims: The aim of this study was to compare the strength of associations and discrimination capability of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) with cardiovascular disease risk in individuals with type-2 diabetes. Methods and results: Eleven thousand, one hundred and forty men and women were followed for a mean of 4.8 years. The Cox proportional hazard models were used to compute the hazard ratios and 95% confidence intervals (95% CI) for one standard deviation (SD) increase in baseline BMI (SD: 5kg/m2), WC (SD: 13cm) and WHR (SD: 0.08) with cardiovascular disease risk. After adjustment, hazard ratio (95% CI) for WC were 1.10 (1.03–1.18) for cardiovascular events, 1.13 (1.03–1.24) for coronary events, and 1.08 (0.98–1.19) for cardiovascular deaths. Estimates for WHR were 1.12 (1.05–1.19), 1.17 (1.08–1.28) and 1.19 (1.09–1.31). BMI was not related to any of these outcomes. Although the receiver operating characteristic curve could not differentiate between anthropometric variables (P values ≤ 0.24), the relative integrated discrimination improvement statistic showed an enhancement in the discrimination capabilities of models using WHR for cardiovascular outcomes, except for cerebrovascular events. Conclusion: Strengths of associations and discrimination statistics suggested that WHR was the best predictor of cardiovascular events and mortality in patients with type-2 diabetes and BMI the worst. © 2011, European Society of Cardiology. All rights reserved.
Authors & Co-Authors
Czernichow, Seb́astien
Australia, Sydney
George Institute for International Health
France, Paris
Conservatoire National Des Arts et Metiers
Kengne, Andre-Pascal Pascal
Australia, Sydney
George Institute for International Health
Huxley, Rachel R.
Australia, Sydney
George Institute for International Health
Batty, George David
Australia, Sydney
George Institute for International Health
United Kingdom, London
Medical Research Council
de Galan, Bastiaan E.
Netherlands, Nijmegen
Radboud Universiteit
Grobbee, Diederick E Egbertus
Netherlands, Utrecht
University Medical Center Utrecht
Zoungas, Sophia
Australia, Sydney
George Institute for International Health
Australia, Clayton
Monash University
Marre, Michel
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Woodward, Mark A.
Australia, Sydney
George Institute for International Health
Neal, Bruce Charles
Australia, Sydney
George Institute for International Health
Chalmers, John P.
Australia, Sydney
George Institute for International Health
Statistics
Citations: 139
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1097/HJR.0b013e32833c1aa3
ISSN:
20474873
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female