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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Initiation of antiretroviral therapy before 6 months of age is associated with faster growth recovery in South African children perinatally infected with human immunodeficiency virus
Journal of Pediatrics, Volume 162, No. 6, Year 2013
Notification
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Description
Objective To describe the effects of age at antiretroviral therapy (ART) initiation on growth outcomes among children infected with HIV followed for 48 months after treatment initiation. Study design This secondary analysis describes anthropometric changes in children infected with HIV in Johannesburg, South Africa who initiated ritonavir-boosted lopinavir-based ART before 24 months of age and were randomized to continue ritonavir-boosted lopinavir or to receive nevirapine after achieving and maintaining virologic suppression. Weight, height, and head circumference were measured at visits over 48 months post- ART initiation. Growth patterns including weight-for-age z-scores (WAZs), height-for-age z-scores, body mass index-for-age z-scores, and head circumference for age z-score were compared between children initiating ART <6 months, 6-12 months, and 12-24 months of age. Results A total of 195 children (mean ± SD age 10.7 ± 5.9 months), including 54 (27.7%) <6 months, 69 (35.4%) 6-12 months, and 72 (36.9%) 12-24 months of age at ART initiation, were evaluated. In the first 12 months on treatment, children <6 months of age at ART initiation experienced more rapid improvement in WAZ (1.98 vs 1.44, P = .084) and head circumference for age z-score (1.24 vs 0.45, P = .004) than children who initiated ART between 12-24 months of age. By 48 months on ART, growth outcomes were similar, regardless of age at ART initiation. WAZ approached population norms by 12 months on ART. Although improving, height-for-age z-scores remained on average 1.0 z-score below population norms at 48 months of therapy. Conclusions Initiation of ART before 6 months of age results in more rapid growth recovery in children infected with HIV. These data provide further evidence for the importance of prompt diagnosis and early initiation of ART for infants infected with HIV. Copyright © 2013 Mosby Inc.
Authors & Co-Authors
Shiau, Stephanie
United States, New York
Gertrude H. Sergievsky Center
United States, New York
Mailman School of Public Health
Arpadi, Stephen M.
United States, New York
Gertrude H. Sergievsky Center
United States, New York
Mailman School of Public Health
Strehlau, Renate
South Africa, Johannesburg
University of the Witwatersrand
Martens, Leigh
South Africa, Johannesburg
University of the Witwatersrand
Patel, Faeezah
South Africa, Johannesburg
University of the Witwatersrand
Coovadia, Ashraf Hassen
South Africa, Johannesburg
University of the Witwatersrand
Abrams, Elaine J.
United States, New York
Mailman School of Public Health
Kuhn, Louise
United States, New York
Gertrude H. Sergievsky Center
United States, New York
Mailman School of Public Health
Statistics
Citations: 53
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jpeds.2012.11.025
ISSN:
00223476
e-ISSN:
10976833
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
South Africa