Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
PfEMP1-DBL1α amino acid motifs in severe disease states of Plasmodium falciparum malaria
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 40, Year 2007
Notification
URL copied to clipboard!
Description
An infection with Plasmodium falciparum may lead to severe malaria as a result of excessive binding of infected erythrocytes in the microvasculature. Vascular adhesion is mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP1), which is encoded for by highly polymorphic members of the var-gene family. Here, we profile var gene transcription in fresh P. falciparum trophozoites from Ugandan children with malaria through var-specific DBL1α-PCR amplification and sequencing. A method for subsectioning region alignments into homology areas (MOTIFF) was developed to examine collected sequences. Specific PfEMP1-DBL1α amino acid motifs correlated with rosetting and severe malaria, with motif location corresponding to distinct regions of receptor interaction. The method is potentially applicable to other families of variant proteins and may be useful in identifying sequence-phenotype relationships. The results suggest that certain PfEMP1 sequences are predisposed to inducing severe malaria. © 2007 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_6.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_7.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_8.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_9.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_10.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_11.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_12.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_13.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_14.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_15.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_16.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_17.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_18.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_19.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_20.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1994139/bin/pnas_0610485104_5.pdf
Authors & Co-Authors
Normark, Johan
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Nilsson, Daniel
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Ribacke, Ulf
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Winter, Gerhard
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Moll, Kirsten
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Wheelock, Craig E.
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Bayarugaba, Justus
Uganda, Kampala
Mulago Hospital
Kironde, Fred Alexander Sekaza
Uganda, Kampala
Makerere University
Egwang, Thomas Gordon
Uganda, Kampala
Med Biotech Laboratories Uganda
Chen, Qijun
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Andersson, Bj�rn
Sweden, Stockholm
Karolinska Institutet
Wahlgren, Mats
Sweden, Stockholm
Karolinska Institutet
Sweden, Solna
Public Health Agency of Sweden
Statistics
Citations: 90
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1073/pnas.0610485104
ISSN:
00278424
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health