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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The prevalence and burden of symptoms amongst cancer patients attending palliative care in two African countries
European Journal of Cancer, Volume 47, No. 1, Year 2011
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Description
Background: The majority of cancer presentations in Africa are advanced and incurable, with incidence of malignancies projected to increase significantly. Despite the African cancer burden, almost nothing is known about the symptomatology of malignant progressive disease. This study aimed to determine the symptom prevalence and burden amongst advanced cancer patients in two African countries. Methods: The Memorial Symptom Assessment Schedule Short Form (MSAS-SF) was used to measure the 7-d period prevalence and associated burden of multidimensional symptoms amongst adult patients attending palliative care in South Africa and Uganda. Further demographic and clinical variables were collected. Results: Of the 112 patients recruited, 22 (19.6%) had an underlying HIV diagnosis. The most common cancer primaries were breast (N = 24), cervix (N = 21) and lung (N = 14). The mean number of symptoms was 18 (SD = 6.6). The five most prevalent symptoms were pain (87.5%), lack of energy (77.7%), feeling sad (75.9%), feeling drowsy (72.3%) and worrying (69.6%). The five symptoms ranked as most severe were as follows: pain n = 26 (23.2%), sexual problems n = 24 (21.4%), weight loss n = 21 (18.8%), 'I don't look like myself' n = 21 (18.8%) and lack of energy n = 20 (17.9%). Discussion: Pain and psychological problems were four of the five most common symptoms, found in more than 3 out of 4 patients. Our sample's reported mean number of symptoms was far higher than reported in other global studies. These data can inform the delivery of appropriate clinical care. The prevalence of multidimensional symptoms underlines the importance of holistic approaches to patient assessment and management, taking account of multiple and potentially interacting symptoms and locally appropriate intervention. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Harding, Richard
United Kingdom, London
King's College London
Ellen Selman, Lucy Ellen
United Kingdom, London
King's College London
Agupio, Godfrey
Uganda, Kampala
Hospice Africa Uganda
Dinat, Natalya
South Africa, Johannesburg
University of the Witwatersrand
Gwyther, Liz
South Africa, Cape Town
Hospice Palliative Care Association of South Africa
Mashao, Thandi
South Africa, Cape Town
University of Cape Town
Mmoledi, Keletso
South Africa, Johannesburg
University of the Witwatersrand
Sebuyira, Lydia Mpanga
Uganda, Kampala
Makerere University
Ikin, Barbara
South Africa, Cape Town
Hospice Palliative Care Association of South Africa
Higginson, Irene J.
United Kingdom, London
King's College London
Statistics
Citations: 107
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1016/j.ejca.2010.08.003
ISSN:
09598049
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
South Africa
Uganda