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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells
Medical Oncology, Volume 25, No. 1, Year 2008
Notification
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Description
The objective of this study is to evaluate the efficacy of epigallocatechin gallate against ATL cells. The anti-proliferative and pro-apoptotic effects of EGCG were evaluated in HTLV-1-positive and -negative cells. EGCG exhibited a marked decrease in proliferation of ATL cells at 96 h of treatment. The results indicated that TGF-α was down-regulated whereas levels of TGF-β2 increased. Cell cycle distribution analysis revealed an increase in cells in the pre-G1 phase which was confirmed by ELISA. The results on proteins showed an up-regulation of p53, Bax and p21 protein levels while the levels of Bcl-2α were down-regulated. © 2007 Humana Press Inc.
Authors & Co-Authors
Harakeh, Steve Mustapha
Lebanon, Beirut
American University of Beirut
Abu-El-Ardat, Khalil A.
Lebanon, Beirut
American University of Beirut
Diab-Assaf, Mona
Lebanon, Beirut
American University of Beirut
Niedzwiecki, Alexandra
United States, Santa Clara
Dr. Rath Research Institute
El-Sabban, Marwan
Lebanon, Beirut
American University of Beirut
Rath, Matthias
United States, Santa Clara
Dr. Rath Research Institute
Statistics
Citations: 44
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/s12032-007-0036-6
Research Areas
Cancer