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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat
Journal of Ethnopharmacology, Volume 94, No. 2-3, Year 2004
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Description
We studied the effect of a 4-week intragastric gavage with a petroleum ether extract of Nigella sativa seeds on blood glucose, insulin and lipids in the normal rat. Petroleum ether extract caused a 25% reduction in food intake that translated into a transient weight loss. No sign of toxicity of the plant could be seen in vivo or in vitro. Fasting plasma glucose remained stable throughout Nigella sativa treatment. At the end of the 4-week treatment, Nigella sativa-treated rats had lower fasting plasma levels of insulin and triglycerides, and higher HDL-cholesterol as compared to pair-fed controls. Response to insulin was evaluated in hepatocytes isolated from animals of all groups by Western blot analysis of phosphorylated MAPK p44/42erk and PKB. In vivo Nigella sativa treatment resulted in greater dose-dependent activation of MAPK and PKB in response to insulin. These results suggest that the petroleum ether extract of Nigella sativa has a slight anorexic effect, and that it contains the hypolipidemic activity previously obtained with the plant. More significantly, our data demonstrate that in vivo treatment with the petroleum ether extract exerts an insulin-sensitizing action by enhancing the activity of the two major intracellular signal transduction pathways of the hormone's receptor. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Le, Phuong Mai
Canada, Montreal
University of Montreal
Canada, Quebec
Université Laval
Benhaddou-Andaloussi, Ali
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Elimadi, Aziz
Canada, Montreal
University of Montreal
Canada, Quebec
Université Laval
Settaf, Abdellatif
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Cherrah, Yahya
Morocco, Rabat
Faculté de Médecine et de Pharmacie de Rabat
Haddad, Pierre Sélim
Canada, Montreal
University of Montreal
Canada, Quebec
Université Laval
Statistics
Citations: 189
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2004.04.030
ISSN:
03788741
Research Areas
Food Security