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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pre-injury stimulant use in isolated severe traumatic brain injury: effect on outcomes
European Journal of Trauma and Emergency Surgery, Volume 49, No. 4, Year 2023
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Description
Purpose: The aim of this study was to assess the impact of pre-injury stimulant use (amphetamine, cocaine, methamphetamine and/or ecstasy) on outcomes after isolated severe traumatic brain injury (TBI). Methods: Retrospective 2017 TQIP study, including adult trauma patients (≥16 years old) who underwent drug and alcohol screening on admission and sustained an isolated severe TBI (head AIS ≥3). Patients with significant extracranial trauma (AIS ≥3) were excluded. Epidemiological and clinical characteristics, procedures and outcome variables were collected. Patients with isolated stimulant use were matched 1:1 for age, gender, mechanism of injury, head AIS and overall comorbidities, with patients with negative toxicology and alcohol screen. Outcomes in the two groups were compared with univariable and multivariable regression analysis. Results: 681 patients with isolated TBI and stimulant use were matched with 681 patients with negative toxicology and alcohol screen. The incidence of hypotension and CGS <9 was similar in the two groups. In multivariable regression analysis, stimulant use was not independently associated with mortality (OR 0.95, 95% CI 0.61–1.49). However, stimulant use was associated with longer hospital length of stay (HLOS) (RC 1.13, 95%CI 1.03–1.24). Conclusion: Pre-injury stimulant use is common in patients admitted for severe TBI, but was not independently associated with mortality when compared to patients with negative toxicology. However, stimulant use was associated with a significant longer HLOS. © 2022, The Author(s).
Authors & Co-Authors
Exadaktylos, Aristomenis Konstantinos
Switzerland, Bern
University of Bern
Demetriades, Demetrios G.
United States, Los Angeles
University of Southern California
Statistics
Citations: 1
Authors: 2
Affiliations: 3
Identifiers
Doi:
10.1007/s00068-022-02095-7
ISSN:
18639933
Research Areas
Health System And Policy
Substance Abuse
Violence And Injury
Study Design
Cohort Study
Study Approach
Quantitative