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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Cell, Volume 140, No. 5, Year 2010
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Description
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution. © 2010 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ravasi, Timothy
Unknown Affiliation
Suzuki, Harukazu
Unknown Affiliation
Cannistraci, Carlo Vittorio
Unknown Affiliation
Katayama, Shintaro
Unknown Affiliation
Bajic, Vladimir B.
Unknown Affiliation
Akalin, Altuna
Unknown Affiliation
Schmeier, Sebastian
Unknown Affiliation
Kanamori-Katayama, Mutsumi
Unknown Affiliation
Bertin, Nicolas
Unknown Affiliation
Carninci, Piero
Unknown Affiliation
Daub, Carsten Olivier
Unknown Affiliation
Forrest, Alistair R.R.
Unknown Affiliation
Gough, Julian
Unknown Affiliation
Grimmond, Sean M.
Unknown Affiliation
Hashimoto, Takehiro
Unknown Affiliation
Hide, Winston A.
Unknown Affiliation
Hofmann, Oliver M.
Unknown Affiliation
Kaur, Mandeep
Unknown Affiliation
Kawaji, Hideya
Unknown Affiliation
Kubosaki, Atsutaka
Unknown Affiliation
Lassmann, Timo
Unknown Affiliation
van Nimwegen, Erik
Unknown Affiliation
MacPherson, Cameron Ross
Unknown Affiliation
Radovanovic, Aleksandar
Unknown Affiliation
Tegnér, Jesper N.
Unknown Affiliation
Lenhard, Boris
Unknown Affiliation
Teichmann, Sarah Amalia
Unknown Affiliation
Arakawa, Takahiro
Unknown Affiliation
Ninomiya, Noriko
Unknown Affiliation
Tagami, Michihira
Unknown Affiliation
Fukuda, Shiro
Unknown Affiliation
Kai, Chikatoshi
Unknown Affiliation
Ishihara, Ryoko
Unknown Affiliation
Kitazume, Yayoi
Unknown Affiliation
Kawai, Jun
Unknown Affiliation
Hume, David A.
Unknown Affiliation
Ideker, Trey E.
Unknown Affiliation
Hayashizaki, Yoshihide
Unknown Affiliation
Statistics
Citations: 567
Authors: 38
Identifiers
Doi:
10.1016/j.cell.2010.01.044
ISSN:
00928674
Research Areas
Genetics And Genomics