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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population
Pan African Medical Journal, Volume 18, Year 2014
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Description
Introduction: Despite the medical progress in treatment. Tuberculosis (TB) continues to be a serious global health problem. A genome-wide linkage study identified a major susceptibility locus on chromosomal region 8q12-q13 in Moroccan TB patients. The CYP7A1 gene is located in this region and codes for cholesterol 7a-hydroxylase, an enzyme involved in cholesterol catabolism. Methods: We selected three SNPs (rs3808607, rs8192875 and rs8192879) and studied their genotype and allele frequencies distribution in patients with pulmonary (PTB) or pleural TB (pTB), and compared them to Healthy Controls (HC). Genotyping of rs8192875 and rs8192879 SNPs was carried out using the Taq Man SNP genotyping Assay while rs3808607 was investigated by PCR-RFLP. Results: We reported here for the first time a statistically significant increase in the AA homozygote genotype frequency of rs3808607 in PTB patients compared to HC (p = 0.02, OR = 1.93, 95% CI: 1.93 (1.07;3.49). The increased risk of developing TB was maintained when we combined the groups of patients (PTB-pTB) (p = 0.01, OR= 1.91, 95% CI = (1.07 - 3.42). In contrast, no genetic association was observed between the rs8192875 or rs8192879 polymorphisms and TB. Conclusion: Our investigations suggest that rs3808607 may play a role in susceptibility to TB in a Moroccan population. © Mounia Qrafli et al.
Authors & Co-Authors
Qrafli, Mounia
Morocco, Agdal Rabat
Institut National D'hygiène
Morocco, Rabat
Mohammed V University in Rabat
Bourkadi, Jamal Eddine
Morocco, Agdal Rabat
Moulay Youssef Hospital
Amor, Jouda Ben
Morocco, Agdal Rabat
Moulay Youssef Hospital
Iraki, Ghali
Morocco, Agdal Rabat
Moulay Youssef Hospital
Bakri, Youssef
Morocco, Rabat
Mohammed V University in Rabat
Amzazi, Saaid
Morocco, Rabat
Mohammed V University in Rabat
Lahlou, Ouafae
Morocco, Agdal Rabat
Institut National D'hygiène
Seghrouchni, Fouad
Morocco, Agdal Rabat
Institut National D'hygiène
El Aouad, Rajae
Morocco, Agdal Rabat
Institut National D'hygiène
Sadki, Khalid
Morocco, Rabat
Mohammed V University in Rabat
Statistics
Citations: 23
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.11604/pamj.2014.18.1.3397
ISSN:
19378688
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study