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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Elevated levels of tumor necrosis factor-α in zairian neonate plasmas: Implications for perinatal infection with the human immunodeficiency virus
Journal of Infectious Diseases, Volume 169, No. 5, Year 1994
Notification
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Description
Plasma levels of tumor necrosis factor-α (TNFα) and the ability of plasmas to induce HIV expression in chronically infected cell lines were measured in samples from adults, cord blood, and neonates from Zaire and North America. Plasma levels of TNFα were higher in Zairian neonates born to HIV-negative and -positive mothers than in uninfected Zairian adults (612 vs. 128 vs. 8 pg/mL, P <.001); this dichotomy persisted until children were 9 months old. Plasmas from neonates of HIV-negative Zairian mothers also stimulated higher levels of reverse transcriptase from HIV-infected cell lines than did plasmas from HIV-negative Zairian adults (1339 vs. 110 cpm, P <.001). Similar patterns were noted in plasmas from HIV-negative North American adults and neonates; however, TNFα levels were markedly lower, and smaller differences were noted among North American adults and neonates than those in the Zairian cohort. Markedly elevated plasma TNFα levels in Zairian neonates and infants may play a role in the pathogenesis and progression of HIV disease in this patient population. © 1994 The University of Chicago.
Authors & Co-Authors
Brown, C.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
United States, Sheridan
Sheridan
Poli, Guido
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Lubaki, Ndongala Michel
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
St-Louis, Michael Ernest
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Davachi, Farzin
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Musey, L.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Manzila, Tarande
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Kovacs, Andrea A.Z.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Quinn, Thomas Charles
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Fauci, Anthony S.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Los Angeles
Los Angeles County Usc Medical Center
United States, Atlanta
Centers for Disease Control and Prevention
Democratic Republic Congo, Kinshasa
Mama Yemo Hospital
Statistics
Citations: 23
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/169.5.975
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study