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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Multi-Fetal Pregnancy, Preeclampsia, and Long-Term Cardiovascular Disease
Hypertension, Volume 76, No. 1, Year 2020
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Description
This Swedish register-based cohort study determined the separate and joint contribution of preeclampsia and multi-fetal pregnancy on a woman's risk of cardiovascular disease (CVD) later in life. The study included 892 425 first deliveries between 1973 and 2010 of women born 1950 until 1971, identified in the Swedish Medical Birth Register. A composite outcome of CVD was retrieved through linkage with the National Patient and Cause of Death Registers. Cox proportional hazard regression was used to assess the risk of CVD in women who had preeclampsia in a singleton or multi-fetal pregnancy, adjusting for potential confounders, and presented as adjusted hazard ratios. Compared with women who had a singleton pregnancy without preeclampsia (the referent group), women with preeclampsia in a singleton pregnancy had an increased risk of CVD (adjusted hazard ratio 1.75 [95% CI, 1.64-1.86]). Women who had a multi-fetal pregnancy without or with preeclampsia did not have an increased risk of future CVD (adjusted hazard ratios 0.94 [95% CI, 0.79-1.10] and 1.25 [95% CI, 0.83-1.86], respectively). As opposed to preeclampsia in a first singleton pregnancy, preeclampsia in a first multi-fetal pregnancy was not associated with increased risk of future CVD. This may support the theory that preeclampsia in multi-fetal pregnancies more often occurs as a result of the larger pregnancy-related burden on the maternal cardiovascular system and excessive placenta-shed inflammatory factors, rather than the woman's underlying cardiovascular phenotype. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Authors & Co-Authors
Bergman, Lina
Sweden, Uppsala
Uppsala Universitet
Sweden, Gothenburg
Göteborgs Universitet
Nordlöf-Callbo, Paliz
Sweden, Uppsala
Uppsala Universitet
Wikstrom̈, Anna Karin
Sweden, Uppsala
Uppsala Universitet
Hesselman, Susanne
Sweden, Uppsala
Uppsala Universitet
Edstedt-Bonamy, Anna Karin
Sweden, Stockholm
Karolinska Institutet
Sandström, Anna
Sweden, Uppsala
Uppsala Universitet
United States, Portland
Oregon Health & Science University
Statistics
Citations: 28
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1161/HYPERTENSIONAHA.120.14860
ISSN:
0194911X
Research Areas
Environmental
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female