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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection - Bacteria and their synergistic potential with antibiotics
Phytomedicine, Volume 19, No. 5, Year 2012
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Description
The aim of this study was to evaluate the antibacterial effect of the association between conventional antibiotics and essential oils (EOs) of endemic Moroccan thyme species, Thymus maroccanus and T. broussonetii, on antibiotic-resistant bacteria involved in nosocomial infections. Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T. Broussonetii EOs were determined by the checkerboard test. Serial dilutions of two antimicrobial agents were mixed together so that each row (and column) contained a fixed amount of the first agent and increasing amounts of the second one. The results indicate that the oils had a high inhibitory activity against tested bacteria, except for Pseudomonas aeruginosa. In parallel with the increase of cellular killing, the release of 260 nm-absorbing materials from bacterial cells, treated with EOs, increased in response to oil concentration. Out of 80 combinations tested between EOs and antibiotics, 71% showed total synergism, 20% had partial synergistic interaction and 9% showed no effect. Combination with carvacrol, the major constituent of T. maroccanus and T. broussonetii, showed also an interesting synergistic effect in combination with ciprofloxacin. The effect on Gram-positive bacteria was more important than on Gram-negative bacteria. These findings are very promising since the use of these combinations for nosocomial infections treatment is likely to reduce the minimum effective dose of the antibiotics, thus minimizing their possible toxic side effects and treatment cost. However, further investigations are needed to assess the potential for therapeutic application. © 2011 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
Fadli, Mariam
Morocco, Marakech
Université Cadi Ayyad
Saad, Asmaa
Morocco, Marakech
Université Cadi Ayyad
Sayadi, Sami
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Chevalier, Jacqueline
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Mezrioui, Noureddine
Morocco, Marakech
Université Cadi Ayyad
Pags, J. M.
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Hassani, Lahcen
Morocco, Marakech
Université Cadi Ayyad
Statistics
Citations: 189
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.phymed.2011.12.003
ISSN:
09447113
e-ISSN:
1618095X
Research Areas
Environmental