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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Antiretroviral Therapy Outcomes among Adolescents and Youth in Rural Zimbabwe
PLoS ONE, Volume 7, No. 12, Article e52856, Year 2012
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Description
Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10-30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10-15 (young adolescents) 15.1-19 years (adolescents), 19.1-24 years (young adults) and 24.1-29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17-4.35). Young adults and adolescents had a 2-3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62-4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults. © 2012 Bygrave et al.
Authors & Co-Authors
Bygrave, Helen
Unknown Affiliation
Mtangirwa, Judith
Unknown Affiliation
Ncube, Kwenzakwenkosi
Unknown Affiliation
Ford, Nathan P.
Unknown Affiliation
Kranzer, Katharina A.
Unknown Affiliation
Munyaradzi, Dhodho
Unknown Affiliation
Statistics
Citations: 96
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0052856
e-ISSN:
19326203
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Locations
Zimbabwe