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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Etiology, antimicrobial susceptibility profiles, and mortality associated with bacterial meningitis among children in Egypt
Annals of Epidemiology, Volume 14, No. 1, Year 2004
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Description
PURPOSE: Surveillance for patients with meningitis is a high priority in order to determine the etiology of disease and design prevention strategies. This study presents data on the causes of bacterial meningitis among children <6 years of age treated in a network of hospitals throughout Egypt. METHODS: Training was provided to standardize the collection of clinical information and optimize recovery of bacterial pathogens. Bacterial isolates were tested for antimicrobial resistance patterns using Kirby Bauer disk diffusion, E-test and/or Beta-lactamase (BL) testing methods. RESULTS: Patients with culture-confirmed bacterial meningitis (228 children<6 years) were identified including 89 (39%) patients with H. influenzae (HI), 68 (30%) with Streptococcus pneumoniae (SP), 30 (13%) with N. meningitidis (NM), 18 (8%) with Mycobacterium tuberculosis (MTB) and 23 (10%) with other bacteria. The overall case fatality ratio was high (24%) and increased among children with TB meningitis (56%). The susceptibility for HI to ampicillin (AMP), chloramphenicol (C) and ceftriaxone (CRO) was 21%, 13%, and 100% respectively. The susceptibility for SP to C and CRO was 79% and 100%, respectively. CONCLUSION: HI and SP are the leading causes of bacterial meningitis among children in Egypt. The majority of HI strains tested were resistant to AMP or C suggesting the need for routine use of CRO as first line therapy. Among older children TB emerges as a significant cause of bacterial meningitis in Egypt. © 2003 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Youssef, Fouad G.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
El-Sakka, Hammam
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Azab, Adel M.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Eloun, Saed
Egypt, Cairo
Egyptian Ministry of Health and Population
Chapman, Gail D.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Ismail, Tharwat F.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Mansour, Hoda
Egypt, Cairo
Egyptian Ministry of Health and Population
Hallaj, Zuhair S.
Switzerland, Geneva
Organisation Mondiale de la Santé
Mahoney, Frank J.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Statistics
Citations: 69
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/S1047-2797(03)00075-9
ISSN:
10472797
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Egypt