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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic characterization of clade B measles viruses isolated in Tunisia and Libya 2002-2009 and a proposed new subtype within the B3 genotype
Virus Research, Volume 153, No. 2, Year 2010
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Description
Genetic characterization was conducted on 18 wild-type measles viruses, detected in Tunisia and Libya from 2002 to 2009. Sequence analysis of the 456 nucleotides in the carboxy terminus of the nucleoprotein (N) gene and the entire hemagglutinin (H) gene indicated that all isolates were in genotype B3. All of the viruses from 2002 to 2007 and some of the isolates from 2009 belonged to subtype B3.1. In contrast, 7 of the viruses isolated during 2008 and 2009 were quite divergent from all B3 isolates. The nucleotide sequences of the N gene of these 7 isolates differed from the sequences of the Ibadan and New York reference strain by an average of 3.1 and 4.4%, respectively. The H gene sequences differed by 1.1 and 2.6% with the same reference strains. This is the first report describing the genetic characteristics of measles viruses from clade B isolated in North Africa; the results suggest that these viruses represent a new subtype of genotype B3. © 2010 Elsevier B.V.
Authors & Co-Authors
Haddad-Boubaker, S.
Tunisia, Tunis
Institut Pasteur de Tunis
Rezq, Moftah
Unknown Affiliation
Smeo, Mohamed
Unknown Affiliation
Ben-Yahia, Ahlem
Tunisia, Tunis
Institut Pasteur de Tunis
Abudher, Abdulhafid
Unknown Affiliation
Slim, Amine Faouzi
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Ghorbel, Mohamed Ben
Tunisia, Tunis
Ministry of Health
Ahmed, Hinda Jama
Switzerland, Geneva
Organisation Mondiale de la Santé
Rota, Paul A.
United States, Atlanta
Centers for Disease Control and Prevention
Triki, Henda
Tunisia, Tunis
Institut Pasteur de Tunis
Statistics
Citations: 14
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.virusres.2010.08.011
ISSN:
01681702
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Libya
Tunisia