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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Incidence of tuberculosis after HAART initiation in a cohort of HIV-positive patients in Burkina Faso
International Journal of Tuberculosis and Lung Disease, Volume 14, No. 3, Year 2010
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Description
OBJECTIVE: To determine the incidence rates of tuberculosis (TB) after the initiation of highly active antiretroviral treatment (HAART). METHODS: We conducted a retrospective cohort study on four human immunodeficiency virus (HIV) treatment centres in Ouagadougou, Burkina Faso. TB incidence was measured at different intervals after HAART initiation. Cox regression models were used to identify factors associated with TB incidence. RESULTS: We analysed a cohort of 2383 subjects with a mean follow-up period of 836 days (standard deviation ± 443.4). TB incidence rate was highest during the first trimester of HAART; after 3 months of treatment, the total TB case incidence dropped by 60% from 5.77/100 person-years (py) to 2.23/100 py. World Health Organization clinical Stage III or IV, CD4+ T-cell count < 50 cells/μl and body mass index (BMI) < 18.5 were associated with increased risk of TB on univariate analysis. In the Cox regression, BMI < 18.5 and CD4+ T-cell count < 50 cells/μl at HAART initiation were independently associated with a two-fold higher risk of TB. CONCLUSIONS: Delaying HAART initiation until the CD4+ T-cell count drops to <50 cells/μl significantly increases TB incidence in the first 3 months after HAART initiation. Active case finding for TB is an essential element of standard clinical care in HIV-positive patients during the initial period of HAART. © 2010 The Union.
Authors & Co-Authors
Dembélé, Mathurin S.
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Saleri, Nuccia
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Italy, Brescia
Università Degli Studi Di Brescia
Carvalho, Anna Cristina Calcada
Italy, Brescia
Università Degli Studi Di Brescia
Saouadogo, Tandaogo
Burkina Faso, Ouagadougou
Ministere de la Sante Ouagadougou
Hien, Alain D.
Switzerland, Geneva
Medecins Sans Frontieres
Zabsonre, Inoussa
Unknown Affiliation
Koala, Samual
Burkina Faso, Ouagadougou
African Solidarity Association-oasis Group
Simpore, J.
Burkina Faso, Ouagadougou
Centre de Recherche Biomoléculaire Pietro Annigoni Cerba
Matteelli, A.
Italy, Brescia
Università Degli Studi Di Brescia
Statistics
Citations: 9
Authors: 9
Affiliations: 5
Identifiers
ISSN:
10273719
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Burkina Faso