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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
High prevalence and diversity of species D adenoviruses (HAdV-D) in human populations of four Sub-Saharan countries
Virology Journal, Volume 11, No. 1, Article 25, Year 2014
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Description
Abstract. Background: Human adenoviruses of species D (HAdV-D) can be associated with acute respiratory illness, epidemic keratoconjunctivitis, and gastroenteritis, but subclinical HAdV-D infections with prolonged shedding have also been observed, particularly in immunocompromised hosts. To expand knowledge on HAdV-D in Sub-Saharan Africa, we investigated the prevalence, epidemiology and pathogenic potential of HAdV-D in humans from rural areas of 4 Sub-Saharan countries, Côte d'Ivoire (CI), Democratic Republic of the Congo (DRC), Central African Republic (CAR) and Uganda (UG). Methods. Stool samples were collected from 287 people living in rural regions in CI, DRC, CAR and UG. HAdV-D prevalence and diversity were determined by PCR and sequencing. A gene block, spanning the genes pV to hexon, was used for analysis of genetic distance. Correlation between adenovirus infection and disease symptoms, prevalence differences, and the effect of age and gender on infection status were analyzed with cross tables and logistic regression models. Results: The prevalence of HAdV-D in the investigated sites was estimated to be 66% in CI, 48% in DRC, 28% in CAR (adults only) and 65% in UG (adults only). Younger individuals were more frequently infected than adults; there was no difference in HAdV-D occurrence between genders. No correlation could be found between HAdV-D infection and clinical symptoms. Highly diverse HAdV-D sequences were identified, among which a number are likely to stand for novel types. Conclusions: HAdV-D was detected with a high prevalence in study populations of 4 Sub-Saharan countries. The genetic diversity of the virus was high and further investigations are needed to pinpoint pathological potential of each of the viruses. High diversity may also favor the emergence of recombinants with altered tropism and pathogenic properties. © 2014 Pauly et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3928611/bin/1743-422X-11-25-S1.doc
Authors & Co-Authors
Pauly, Maude S.
Germany, Berlin
Robert Koch Institute
Hoppe, Eileen
Germany, Berlin
Robert Koch Institute
Mugisha, Lawrence
Uganda, Kampala
Makerere University
Uganda, Kampala
Conservation and Ecosystem Health Alliance Ceha
Petrželková, Klára Judita
Czech Republic, Brno
Institute of Vertebrate Biology of the Academy of Sciences of the Czech Republic
Czech Republic, Brno
Veterinární Univerzita Brno
Akoua-Koffl, Chantal Gnankon
Cote D'ivoire, Bouake
Université Alassane Ouattara
Couacy-Hymann, Emmanuel
Cote D'ivoire
Lanada/laboratoire Central de Pathologie Animale
Anoh, Augustin Etile
Cote D'ivoire, Bouake
Université Alassane Ouattara
Mossoun, Arsène M.
Cote D'ivoire
Lanada/laboratoire Central de Pathologie Animale
Schubert, Grit
Germany, Berlin
Robert Koch Institute
Wiersma, Lidewij
Netherlands, Rotterdam
Erasmus Mc
Pascale, Sabwe
Congo
Institut National de Recherche Biomédicale
Muyembe-Tamfum, Jean Jacques
Congo
Institut National de Recherche Biomédicale
Karhemere, Stomy Bin Shamamba
Congo
Institut National de Recherche Biomédicale
Weiss, Sabrina
Germany, Berlin
Robert Koch Institute
Leendertz, Siv Aina Jensen
Germany, Berlin
Robert Koch Institute
Calvignac-Spencer, Sébastien
Germany, Berlin
Robert Koch Institute
Leendertz, Fabian Hubertus
Germany, Berlin
Robert Koch Institute
Ehlers, Bernhard
Germany, Berlin
Robert Koch Institute
Statistics
Citations: 18
Authors: 18
Affiliations: 9
Identifiers
Doi:
10.1186/1743-422X-11-25
e-ISSN:
1743422X
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Central African Republic
Congo
Ivory Coast
Uganda