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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genotypic and phenotypic characterization of viral isolates from HIV-1 subtype C-infected children with slow and rapid disease progression
AIDS Research and Human Retroviruses, Volume 22, No. 5, Year 2006
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Description
The genotypes and biological phenotypes of HIV-1 isolates obtained from 40 perinatally infected children in South Africa were analyzed. This included 15 infants who had HIV-related symptoms, most of whom died within 2 years of birth (rapid progressors), and 25 children who survived between 4 and 9 years with varying signs of disease (slow progressors). Heteroduplex mobility assays and sequence analysis confirmed that within the env and gag regions, all isolates were HIV-1 subtype C. Viral isolates from 14 of the 15 rapid progressors used the CCR5 coreceptor, whereas 1 (02ZARP1) used both the CXCR4 and CCR5 coreceptors. Among the 25 slow progressors, 22 isolates used CCR5 only, 2 used CXCR4 only, and 1 used both CCR5 and CXCR4. Two of the slow-progressing children who harbored CXCR4-using viruses had AIDS. All four CXCR4-using viruses had genotypic changes in the V3 region previously shown to be associated with CXCR4 usage. This cross-sectional study shows that HIV-1 subtype C viruses from both rapid- and slow-progressing perinatally infected children used predominantly CCR5. Similar to adults, CXCR4 usage was uncommon among HIV-1 subtype C isolates from pediatric infections. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Choge, Isaac A.
South Africa, Johannesburg
National Institute for Communicable Diseases
Cilliers, Tonie
South Africa, Johannesburg
National Institute for Communicable Diseases
Walker, Polly R.
South Africa, Johannesburg
National Institute for Communicable Diseases
United Kingdom, Oxford
University of Oxford
Taylor, Natasha
South Africa, Johannesburg
National Institute for Communicable Diseases
Phoswa, Mary
South Africa, Johannesburg
National Institute for Communicable Diseases
Meyers, Tammy M.M.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Viljoen, Johannes I.
South Africa, Bloemfontein
University of the Free State
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Violari, Avy
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Gray, Glenda E.
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Moore, Penny L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Papathanosopoulos, Maria
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
School of Clinical Medicine
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Statistics
Citations: 55
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1089/aid.2006.22.458
ISSN:
08892229
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
South Africa