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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts
Liver International, Volume 34, No. 3, Year 2014
Notification
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Description
Background & Aims: There is a demand for more sensitive, specific and predictive biomarkers for drug-induced liver injury (DILI) than the gold standard used today, alanine aminotransferase (ALT). The aim of this study was to qualify novel DILI biomarkers (keratin-18 markers M65/M30, microRNA-122, glutamate dehydrogenase and alpha-foetoprotein) in human DILI. Methods: Levels of the novel biomarkers were measured by enzyme-linked immunosorbent assay or real-time quantitative reverse-transcription PCR (qRT-PCR) in two human DILI cohorts: a human volunteer study with acetaminophen and a human immunodeficiency virus (HIV)/tuberculosis (TB) study. Results: In the acetaminophen study, serum M65 and microRNA-122 levels were significantly increased at an earlier time point than ALT. Furthermore, the maximal elevation of M65 and microRNA-122 exceeded the increase in ALT. In the HIV/TB study, all the analysed novel biomarkers increased after 1 week of treatment. In contrast to ALT, the novel biomarkers remained stable in a human cohort with exercise-induced muscular injury. Conclusions: M65 and microRNA-122 are potential biomarkers of DILI superior to ALT with respect to sensitivity and specificity. © 2013 John Wiley & Sons A/S.
Authors & Co-Authors
Thulin, Petra
Sweden, Sodertalje
Astrazeneca Sweden
Nordahl, Gunnar
Sweden, Sodertalje
Astrazeneca r and D Södertälje
Gry, Marcus
Sweden, Sodertalje
Astrazeneca r and D Södertälje
Yimer, Getnet
Ethiopia, Addis Ababa
School of Medicine
Aklillu, Eleni
Sweden, Stockholm
Karolinska Universitetssjukhuset
Makonnen, Eyasu
Ethiopia, Addis Ababa
School of Medicine
Aderaye, Getachew
Ethiopia, Addis Ababa
School of Medicine
Lindquist, Lars
Sweden, Stockholm
Karolinska Universitetssjukhuset
Mattsson, C. Mikael
Sweden, Stockholm
Karolinska Institutet
Ekblöm, Björn T.
Sweden, Stockholm
Karolinska Institutet
Antoine, D. J.
United Kingdom, Liverpool
University of Liverpool
Park, B. Kevin
United Kingdom, Liverpool
University of Liverpool
Linder, Stig
Sweden, Stockholm
Karolinska Universitetssjukhuset
Harrill, Alison H.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Watkins, Paul B.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Glinghammar, Björn
Sweden, Sodertalje
Astrazeneca Sweden
Schuppe-Koistinen, Ina
Sweden, Sodertalje
Astrazeneca Sweden
Statistics
Citations: 107
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1111/liv.12322
ISSN:
14783223
e-ISSN:
14783231
Research Areas
Infectious Diseases
Violence And Injury
Study Design
Cohort Study
Study Approach
Quantitative