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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
AIDS-Associated Non-Hodgkin’s Lymphoma in San Francisco
JAMA: The Journal of the American Medical Association, Volume 261, No. 5, Year 1989
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Description
The characteristics of acquired immunodeficiency syndrome—associated non-Hodgkin’s lymphoma in 84 patients diagnosed and treated at San Francisco General Hospital are presented herein. While the majority were high-grade B-cell lymphomas, one cutaneous T-cell and one peripheral T-cell lymphoma were observed. In addition, three other tumors were suspicious for T-cell lymphoma. Sixty-seven percent of patients had stage IV disease, often at unusual sites. Epstein-Barr virus DNA sequences were identified in only five of 15 tumors by dot-blot analysis. Patients were treated with a variety of standard chemotherapeutic regimens, with radiation therapy alone, or with a novel chemotherapy protocol (COMET-A). No significant differences in complete response rates were observed. The most important predictor of survival was the total number of CD4-positive lymphocytes. Other predictors of survival included history of a diagnosis of acquired immunodeficiency syndrome, Karnofsky performance score, and the presence of extranodal disease. Survival was shorter among patients who received higher doses of cyclophosphamide (>1 g/m2), including those treated with the COMET-A regimen. Implications for therapeutic decision making are discussed. © 1989, American Medical Association. All rights reserved.
Authors & Co-Authors
Feigal, Ellen G.
United States, San Francisco
San Francisco General Hospital and Trauma Center
McGrath, Michael S.
United States, San Francisco
San Francisco General Hospital and Trauma Center
Ziegler, John L.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 398
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1001/jama.1989.03420050069041
ISSN:
00987484
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases