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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Early interferon-γ response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric fulani and dogon in mali
Journal of Infectious Diseases, Volume 201, No. 1, Year 2010
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Description
Introduction. Interethnic differences in susceptibility to malaria provide a unique opportunity to explore immunological correlates of protection. The Fulani of Sahelian Africa are known for their reduced susceptibility to Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood. Methods and Results. Here, we show that mononuclear cells from Fulani elicit >10-fold stronger interferon (IFN)-γ production following a 24-h in vitro coincubation with asexual parasites than cells from sympatric Dogon. This response appears to be specific for P falciparum among a panel of other human pathogens and is independent of the lower number of regulatory T cell counts present in Fulani. IFN-γ responses in both tribes were inversely correlated with peripheral parasite density as quantified by nucleic acid sequenced-based amplification, but responses of Fulani remained significantly stronger than those of Dogon after adjustment for concurrent parasitemia, suggesting that hard-wired immunological differences underlie the observed protection. Conclusions. These results underscore the value of early IFN-γ responses to P falciparum as a correlate of anti-parasite immunity, not only in this setting but also in the wider context of malaria, and support the development of malaria vaccines aimed at inducing such responses. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
McCall, Matthew B.B.
Unknown Affiliation
Hopman, Joost
Unknown Affiliation
Daou, Modibo
Unknown Affiliation
Maïga, Boubacar B.
Unknown Affiliation
Dara, Victor
Unknown Affiliation
Ploemen, Ivo H.J.
Unknown Affiliation
Nganou-Makamdop, Krystelle
Unknown Affiliation
Niangaly, Amadou B.
Unknown Affiliation
Tolo, Youssouf
Unknown Affiliation
Arama, Charles
Unknown Affiliation
Bousema, J. Teun
Unknown Affiliation
van der Meer, Jos W.M.D.
Unknown Affiliation
van der Ven, André J.A.M.
Unknown Affiliation
Troye-Blomberg, Marita
Unknown Affiliation
Dolo, Amagana I.
Unknown Affiliation
Doumbo, Ogobara K.
Unknown Affiliation
Sauerwein, Robert W.
Unknown Affiliation
Statistics
Citations: 63
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1086/648596
ISSN:
00221899
Research Areas
Infectious Diseases
Study Locations
Mali