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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differentiation of tuberculous meningitis from acute bacterial meningitis using simple clinical and laboratory parameters
Diagnostic Microbiology and Infectious Disease, Volume 55, No. 4, Year 2006
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Description
Tuberculous meningitis (TBM) is still a major cause of serious illness in many parts of the world. The newer diagnostic tests and neuroimaging methods are unlikely to be available in many developing countries. We attempt to identify simple parameters for early diagnosis. A retrospective study was performed to compare the clinical and laboratory features of cultured-confirmed, TBM (134) and other bacterial meningitis (709). Features independently predictive of TBM were studied by multivariate logistic regression to develop a diagnostic rule. Six features were found predictive: length of clinical history >5 days, headache, total cerebrospinal fluid (CSF) white blood cell count of <1000/mm3, clear appearance of CSF, lymphocyte proportion of >30%, and protein content of >100 mg/dL. Application of 3 or more parameters revealed 93% sensitivity and 77% specificity. Applying this diagnostic rule can help in the early diagnosis of TBM, in both children and adults. © 2006 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Youssef, Fouad G.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Afifi, Salma A.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Azab, Adel M.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Wasfy, M. O.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Abdel-Aziz, Khalid M.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Parker, Tina M.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Oun, Said Ali
Egypt, Cairo
Egyptian Ministry of Health and Population
Jobanputra, Nishith N.
United States, Bethesda
Uniformed Services University of the Health Sciences
Hajjeh, Rana A.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 98
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.diagmicrobio.2006.01.027
ISSN:
07328893
Research Areas
Maternal And Child Health
Study Design
Cohort Study