Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
IPT in people living with HIV in Myanmar: A five-fold decrease in incidence of TB disease and all-cause mortality
International Journal of Tuberculosis and Lung Disease, Volume 23, No. 3, Year 2019
Notification
URL copied to clipboard!
Description
S E T T ING: Myanmar, a country with a high human immunodeficiency virus-tuberculosis (HIV-TB) burden, where the tuberculin skin test or interferon-gamma release assays are not routinely available for the diagnosis of latent tuberculous infection. OBJECTIVE : To assess the effect of isoniazid (INH) preventive therapy (IPT) on the risk of TB disease and mortality among people living with HIV (PLHIV). DES IGN: A retrospective cohort study of routinely collected data on PLHIV enrolled into care between 2009 and 2014. RE SULT S : Of 7177 patients (median age 36 years, interquartile range 31-42; 53% male) included in the study, 1278 (18%) patients received IPT. Among patients receiving IPT, 855 (67%) completed 6 or 9 months of INH. Patients who completed IPT had a significantly lower risk of incident TB than those who never received IPT (adjusted hazard ratio [aHR] 0.21, 95%CI 0.12-0.34) after controlling for potential confounders. PLHIV who received IPT had a significantly lower risk of death than those who never received IPT (PLHIV who completed IPT, aHR 0.25, 95%CI 0.16- 0.37; those who received but did not complete IPT, aHR 0.55, 95%CI 0.37-0.82). CONCLUSION: Among PLHIV in Myanmar, completing a course of IPT significantly reduced the risk of TB disease, and receiving IPT significantly reduced the risk of death. © 2019 The Union.
Authors & Co-Authors
Kumar, Ajay M.V.
France, Paris
The Union
Kyaw, Khine Wut Yee
France, Paris
International Union Against Tuberculosis and Lung Disease
Satyanarayana, Srinath
India, New Delhi
South-east Asia Office
Magee, Matthew James
United States, Atlanta
Georgia State University
Aung, Thet Ko
France, Paris
International Union Against Tuberculosis and Lung Disease
Oo, Myo Minn
France, Paris
International Union Against Tuberculosis and Lung Disease
Soe, Kyaw Thu
Unknown Affiliation
Oo, Htun Nyunt
Unknown Affiliation
Aung, Si Thu
Myanmar, Nay Pyi Taw
National Tuberculosis Program
Harries, Anthony David
France, Paris
The Union
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 2
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.5588/ijtld.18.0448
ISSN:
10273719
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male