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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area
Journal of Infectious Diseases, Volume 191, No. 10, Year 2005
Notification
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Description
To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the C-terminal portion of merozoite surface protein 1 (MSP119), apical membrane antigen 1 (AMA1), and the cysteine-rich interdomain region 1α (CIDR1α) of a protein from the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. These data are the first to be generated on memory B cells in children who are in the process of acquiring antimalarial immunity, and they reveal defects in B cell memory to P. falciparum antigens. Compared with the results for tetanus toxoid, more donors who were positive for antibody to AMA1 and CIDR1α were negative for memory B cells. These data imply that some exposures to malaria do not result in the establishment of stable populations of circulating antigen-specific memory B cells, suggesting possible mechanisms for the short-lived nature of many anti-malarial antibody responses. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Dorfman, Jeffrey R.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Kenya, Nairobi
Kenya Medical Research Institute
Bejon, Philip A.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Ndung'u, Francis M.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, London
Mrc National Institute for Medical Research
Langhorne, Jean
United Kingdom, London
Mrc National Institute for Medical Research
Kortok, Moses Mosobo
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Lowe, Brett S.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Mwangi, Tabitha Wanja
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Williams, Thomas Neil
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Marsh, Kevin
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United Kingdom, Oxford
Churchill Hospital
Statistics
Citations: 120
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1086/429671
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health