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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Primary immunodeficiencies: A 27-year review at a tertiary paediatric hospital in Cape Town, South Africa
Journal of Clinical Immunology, Volume 31, No. 1, Year 2011
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Description
Introduction: The epidemiology of primary immunodeficiencies (PID) is not well documented in Africa. The objective of this study was to describe the spectrum of PID at a tertiary paediatric centre in South Africa. Methods: A retrospective study was conducted on 168 patients diagnosed with PID from 1983 to 2009. Results: Over the study period, antibody deficiencies predominated (51%) followed by well-defined syndromes (24%). Common variable immunodeficiency was the commonest antibody deficiency. The mean age of diagnosis was 51 months overall but decreased significantly to 35 months over the last 9 years. Recurrent infections were the most common presenting complaint (74%). The overall mortality rate was 25% while combined immunodeficiencies accounted for 40% of the deaths. Conclusions: The spectrum of PID in South Africa was similar to international trends. The declining mean age of diagnosis indicated improved recognition of PID. Future research should focus on identifying children with PID more effectively. © 2010 Springer Science+Business Media, LLC.
Authors & Co-Authors
Naidoo, Reené
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Ungerer, Lisa
South Africa, Cape Town
Red Cross War Memorial Children's Hospital
Cooper, Margaret
South Africa, Cape Town
University of Cape Town
Pienaar, Sandra M.
South Africa, Cape Town
University of Cape Town
Eley, Brian S.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 37
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1007/s10875-010-9465-7
ISSN:
02719142
e-ISSN:
15732592
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Locations
South Africa